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Titolo:
Growth characteristics and imaging properties of the Morris hepatoma 3924Ain ACI rats: A suitable model for transarterial chemoembolization
Autore:
Trubenbach, J; Graepler, F; Pereira, PL; Ruck, P; Lauer, U; Gregor, M; Claussen, CD; Huppert, PE;
Indirizzi:
Univ Hosp Tubingen, Dept Diagnost Radiol, D-72076 Tubingen, Germany Univ Hosp Tubingen Tubingen Germany D-72076 l, D-72076 Tubingen, Germany
Titolo Testata:
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
fascicolo: 3, volume: 23, anno: 2000,
pagine: 211 - 217
SICI:
0174-1551(200005/06)23:3<211:GCAIPO>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSCATHETER ARTERIAL EMBOLIZATION; RANDOMIZED CLINICAL-TRIAL; HEPATOCELLULAR-CARCINOMA; LIVER-CANCER; PATTERNS; TUMORS; MRI;
Keywords:
hepatoma; animal model; transarterial chemoembolization; angiography; ultrasound; magnetic resonance imaging; computed tomography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Trubenbach, J Univ Hosp Tubingen, Dept Diagnost Radiol, Hoppe Seyler Str 3, D-72076 Tubingen, Germany Univ Hosp Tubingen Hoppe Seyler Str 3 TubingenGermany D-72076
Citazione:
J. Trubenbach et al., "Growth characteristics and imaging properties of the Morris hepatoma 3924Ain ACI rats: A suitable model for transarterial chemoembolization", CARDIO IN R, 23(3), 2000, pp. 211-217

Abstract

Purpose: For experimental studies investigating modalities and efficacy oftransarterial chemoembolization (TACE) in hepatocellular carcinoma (HCC) an animal model resembling the human situation as closely as possible would be appropriate, Specifically, reproducible turner growth characteristics with the capability for appropriate in vivo imagine to monitor treatment efficacy are required. Methods: Morris hepatoma 3924A was implanted into the liver of 30 ACI rats. Tumor growth was followed by angiography (n = 10), ultrasound (US, II = 30), native computed tomography (CT, n = 16), and native magnetic resonance imaging (MRI, n = 30) between day 8 and day 36 after implantation. The radiological morphological characteristics were compared with the macroscopic and microscopic histological findings of the explanted tumors. Results: In all 30 animals a solitary liver tumor was found and macroscopically no signs of metastases, ascites, or peritoneal tumor were visible. Onhistopathological examination tumor sizes ranged between 27 +/- 3 mm(3) (day 8) and 3468 +/- 79 mm(3) (day 36). The first signs of tumor necrosis occurred at day 16, US allowed tumor visualization from day 8, MRI from day 8,angiography from day 10, and CT from day 14. Conclusions: The tumor model has the potential to be used for the visualization of tumor growth by MRI and US. The potential for monitoring therapeutic effects of TACE needs to be investigated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 07:03:55