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Titolo:
Increased expression of Fas (APO-1, CD95) on CD34(+) haematopoietic progenitor cells after allogeneic bone marrow transplantation
Autore:
Saheki, K; Fujimori, Y; Takemoto, Y; Kakishita, E;
Indirizzi:
Hyogo Coll Med, Dept Internal Med 2, Nishinomiya, Hyogo 6638501, Japan Hyogo Coll Med Nishinomiya Hyogo Japan 6638501 miya, Hyogo 6638501, Japan
Titolo Testata:
BRITISH JOURNAL OF HAEMATOLOGY
fascicolo: 2, volume: 109, anno: 2000,
pagine: 447 - 452
SICI:
0007-1048(200005)109:2<447:IEOF(C>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYELODYSPLASTIC SYNDROMES; ANTIGEN CD95; RECONSTITUTION; APOPTOSIS; LIGAND; ANEMIA; DEATH;
Keywords:
Fas/APO-1 (CD95); bone marrow transplantation; progenitors; CD34; haematopoiesis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Fujimori, Y Hyogo Coll Med, Dept Internal Med 2, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 6638501, Japan Hyogo Coll Med 1-1 Mukogawa-cho Nishinomiya Hyogo Japan 6638501
Citazione:
K. Saheki et al., "Increased expression of Fas (APO-1, CD95) on CD34(+) haematopoietic progenitor cells after allogeneic bone marrow transplantation", BR J HAEM, 109(2), 2000, pp. 447-452

Abstract

tip-regulation of Fas/APO-1 (CD95) on haematopoietic progenitors and Fas-mediated apoptosis have been suggested to occur in a possible pathological mechanism in some bone marrow failure syndromes. We examined the expression of Fas antigen and susceptibility to Fas-mediated suppression of donor-derived haematopoietic cells of allogeneic bone marrow transplantation (BMT) recipients. Cytofluorometric analysis revealed low expression of Fas on CD34() bone marrow cells from marrow donors or healthy cent-rots, However, significantly higher expression of Fas antigen was observed on CD34(+) bone marrow cells of BMT recipients, in whom engraftment of donor bone marrow (BM) cells was confirmed, The addition of an agonistic anti-Fas antibody (Ab) (CH-11) to haematopoietic stem cell culture of BM cells more strongly suppressed colony formation from granulocyte-macrophage colony-forming units (GM-CFU) and erythroid burst-forming units (BFU-E) after BMT. Pretreatment by blocking anti-Fas Ab (ZB4) abrogated the Fas-mediated GM-CFU and BFU-E suppression. Purified marrow CD34+ cells from BMT recipients were also susceptible to the Fas-mediated colony suppression, Thus, donor-derived CD34(+) haematopoietic cells increased their expression of Fas antigen and were susceptible to Fas-mediated haematopoietic suppression. These findings provide new insight for understanding the haematological condition after BMT.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 00:58:05