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Titolo:
Scleroderma and related disorders: therapeutic aspects
Autore:
Denton, CP; Black, CM;
Indirizzi:
Royal Free & Univ Coll Med Sch, Ctr Rheumatol, London NW3 2PF, England Royal Free & Univ Coll Med Sch London England NW3 2PF n NW3 2PF, England
Titolo Testata:
BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY
fascicolo: 1, volume: 14, anno: 2000,
pagine: 17 - 35
SICI:
1521-6942(200003)14:1<17:SARDTA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYSTEMIC-SCLEROSIS SCLERODERMA; DIFFUSE CUTANEOUS SCLERODERMA; RAYNAUDS-PHENOMENON SECONDARY; VERSUS-HOST DISEASE; DOUBLE-BLIND; CYCLOSPORINE-A; PULMONARY-HYPERTENSION; ILOPROST INFUSION; COLLAGEN-SYNTHESIS; CLINICAL-TRIALS;
Keywords:
scleroderma; systemic sclerosis; Raynaud's; therapy; evaluation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
73
Recensione:
Indirizzi per estratti:
Indirizzo: Black, CM Royal Free & Univ Coll Med Sch, Ctr Rheumatol, Royal Free Campus,Rowland Hill St, London NW3 2PF, England Royal Free & Univ Coll Med Sch Royal Free Campus,Rowland Hill St London England NW3 2PF
Citazione:
C.P. Denton e C.M. Black, "Scleroderma and related disorders: therapeutic aspects", BEST PR R C, 14(1), 2000, pp. 17-35

Abstract

Improvements in management of systemic sclerosis have occurred through a growing understanding of pathogenic events accompanied by advances in diagnosis and assessment, as well as developments in organ-based therapeutics. Unfortunately, disease-modifying therapies of proven efficacy remain elusive and several agents in current use have been shown in well-controlled clinical trials to be of questionable benefit. More positively, there have been advances in the treatment of major visceral complications such as renal crisis, pulmonary fibrosis, pulmonary hypertension, gastrointestinal involvement and in the management of scleroderma-associated Raynaud's phenomenon. Current approaches are reviewed, evidence supporting or refuting the use of putative disease-modifying agents is discussed, and new strategies are described that are currently being considered for this fascinating but complex multisystem connective tissue disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 05:28:38