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Titolo:
The genetics of smoking initiation and quantity smoked in Dutch adolescentand young adult twins
Autore:
Koopmans, JR; Slutske, WS; Heath, AC; Neale, MC; Boomsma, DI;
Indirizzi:
Free Univ Amsterdam, Dept Biol Psychol, NL-1081 HV Amsterdam, Netherlands Free Univ Amsterdam Amsterdam Netherlands NL-1081 HV terdam, Netherlands Univ Missouri, Dept Psychol, Columbia, MO 65211 USA Univ Missouri Columbia MO USA 65211 Dept Psychol, Columbia, MO 65211 USA Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA WashingtonUniv St Louis MO USA 63110 pt Psychiat, St Louis, MO 63110 USA Virginia Commonwealth Univ, Dept Human Genet, Richmond, VA 23284 USA Virginia Commonwealth Univ Richmond VA USA 23284 , Richmond, VA 23284 USA
Titolo Testata:
BEHAVIOR GENETICS
fascicolo: 6, volume: 29, anno: 1999,
pagine: 383 - 393
SICI:
0001-8244(199911)29:6<383:TGOSIA>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALCOHOL-CONSUMPTION PATTERNS; NICOTINE DEPENDENCE; SUBSTANCE USE; QUESTIONNAIRE; DETERMINANTS; INHERITANCE; FREQUENCY; ZYGOSITY; TOBACCO; SAMPLE;
Keywords:
smoking initiation; quantity smoked; genetic influences; Dutch twins; adolescents; young adults;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Koopmans, JR Free Univ Amsterdam, Dept Biol Psychol, De Boelelaan 1111, NL-1081 HV Amsterdam, Netherlands Free Univ Amsterdam De Boelelaan 1111 Amsterdam Netherlands NL-1081 HV
Citazione:
J.R. Koopmans et al., "The genetics of smoking initiation and quantity smoked in Dutch adolescentand young adult twins", BEHAV GENET, 29(6), 1999, pp. 383-393

Abstract

Not much is known about the genetic and environmental determinants of various aspects of substance use in adolescents. This study examined whether the inheritance of initiation of tobacco use in adolescents is independent ofthe inheritance of the number of cigarettes smoked. Alternative multifactorial threshold models were applied to data on tobacco use in 1676 Dutch adolescent twin pairs. The three models that were considered are (i) the single liability dimension model, (ii) the independent liability dimension model, and (iii) the combined model (CM), The results showed that there is not one underlying continuum of liability to smoking. The CM was the best-fitting model. This model postulates that there are separate initiation and quantity dimensions but allows for the possibility that there are some individuals who are so low on the liability to level of consumption that they are not using tobacco. There were no differences between males and females in themagnitude of the genetic and environmental influences on individual differences in smoking initiation and quantity smoked. Smoking initiation was influenced by genetic factors (39%) and shared environmental influences (54%),Once smoking is initiated genetic factors determine to a large extent (86%) the quantity that is smoked.

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Documento generato il 20/01/20 alle ore 04:51:27