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Titolo:
Does adjustment of GFR to extracellular fluid volume improve the clinical utility of cystatin C?
Autore:
Kilpatrick, ES; Keevil, BG; Addison, GM;
Indirizzi:
Hull Royal Infirm, Dept Clin Biochem, Hull HU3 2JZ, N Humberside, England Hull Royal Infirm Hull N Humberside England HU3 2JZ N Humberside, England Wythenshawe Hosp, Manchester M23 9LT, Lancs, England Wythenshawe Hosp Manchester Lancs England M23 9LT M23 9LT, Lancs, England Royal Manchester Childrens Hosp, Manchester, Lancs, England Royal Manchester Childrens Hosp Manchester Lancs England Lancs, England
Titolo Testata:
ARCHIVES OF DISEASE IN CHILDHOOD
fascicolo: 6, volume: 82, anno: 2000,
pagine: 499 - 502
SICI:
0003-9888(200006)82:6<499:DAOGTE>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLOMERULAR-FILTRATION-RATE; CHILDREN; MARKER; NORMALIZATION; CREATININE;
Keywords:
cystatin C; glomerular filtration rate;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Kilpatrick, ES Hull Royal Infirm, Dept Clin Biochem, Anlaby Rd, Hull HU3 2JZ, N Humberside, England Hull Royal Infirm Anlaby Rd Hull N Humberside England HU3 2JZ
Citazione:
E.S. Kilpatrick et al., "Does adjustment of GFR to extracellular fluid volume improve the clinical utility of cystatin C?", ARCH DIS CH, 82(6), 2000, pp. 499-502

Abstract

Background-Cystatin C measurement has been proposed as a replacement for creatinine as a serum measure of glomerular filtration rate (GFR). It has also been suggested that GFR itself should be adjusted to the extracellular fluid volume (ECV) of a child rather than the body surface area (BSA). Aims-To assess the potential of cystatin C compared to serum creatinine inassessing GFR and to establish whether adjustment of GFR to ECV rather than BSA affects the potential usefulness of cystatin C. Methods-Cystatin C and plasma creatinine were measured in 64 paediatric patients undergoing 77 Cr-51-EDTA GFR measurements over a six month period. Results-1/cystatin C concentrations were more closely related to GFR (median 98 ml/min/1.73 m(2), range 8-172) after adjustment for patient BSA (r = 0.81 versus r = 0.44). 1/Creatinine concentrations appeared to be an inferior estimate of BSA adjusted GFR (r = 0.41), even following the use of the Schwartz formula (r = 0.37). Bland Altman statistics showed cystatin C couldstill only predict 95% of GFR values to within +/-41 ml/min/1.73 m2 of theCr-51-EDTA method. The relation between GFR and 1/cystatin C was not improved by adjusting Cr-51-EDTA GFR to ECV rather than BSA (r = 0.76 versus 0.81). Conclusions-Cystatin C appears superior to serum creatinine in paediatric subjects although its performance is unlikely to supplant 51Cr-EDTA GFR measurement. This performance is not being underestimated because of adjustingGFR to BSA rather than ECV.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 10:44:36