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Titolo:
Concentrations of substance P and prostaglandin E-2 in synovial fluid of normal and abnormal joints of horses
Autore:
Kirker-Head, CA; Chandna, VK; Agarwal, RK; Morris, EA; Tidwell, A; OCallaghan, MW; Rand, W; Kumar, MSA;
Indirizzi:
Tufts Univ, Sch Vet Med, Dept Surg, N Grafton, MA 01536 USA Tufts Univ N Grafton MA USA 01536 Med, Dept Surg, N Grafton, MA 01536 USA Tufts Univ, Sch Vet Med, Dept Med, N Grafton, MA 01536 USA Tufts Univ N Grafton MA USA 01536 Med, Dept Med, N Grafton, MA 01536 USA Tufts Univ, Sch Vet Med, Dept Anat & Cell Biol, N Grafton, MA 01536 USA Tufts Univ N Grafton MA USA 01536 at & Cell Biol, N Grafton, MA 01536 USA Dept Family Med & Community Hlth, Boston, MA 02111 USA Dept Family Med & Community Hlth Boston MA USA 02111 Boston, MA 02111 USA Genet Inst, Andover, MA 01810 USA Genet Inst Andover MA USA 01810Genet Inst, Andover, MA 01810 USA
Titolo Testata:
AMERICAN JOURNAL OF VETERINARY RESEARCH
fascicolo: 6, volume: 61, anno: 2000,
pagine: 714 - 718
SICI:
0002-9645(200006)61:6<714:COSPAP>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; GENE-RELATED PEPTIDE; RHEUMATOID-ARTHRITIS; KNEE-JOINT; ACUTE-INFLAMMATION; PATHO-PHYSIOLOGY; NERVOUS-SYSTEM; EARLY EXPOSURE; NEUROKININ-A; DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Kirker-Head, CA Tufts Univ, Sch Vet Med, Dept Surg, N Grafton, MA 01536 USA Tufts Univ N Grafton MA USA 01536 N Grafton, MA 01536 USA
Citazione:
C.A. Kirker-Head et al., "Concentrations of substance P and prostaglandin E-2 in synovial fluid of normal and abnormal joints of horses", AM J VET RE, 61(6), 2000, pp. 714-718

Abstract

Objective-To correlate substance P content of synovial fluid with prostaglandin E-2 content, radiographic evidence of joint abnormality, and anatomiclocation of the joint for normal and osteoarthritic joints of horses. Sample Population-Synovial fluid from 46 normal joints in 21 horses and 16osteoarthritic joints in 10 horses. Procedure-Normal and osteoarthritic joints were identified by clinical andradiographic examination, by response to nerve blocks, during scintigraphyor surgery, or by clinicopathologic evaluation. Substance P and prostaglandin E-2 contents of synovial fluid were determined by radioimmunoassay. Radio-graphs of joints were assigned a numeric score reflecting severity of lesions. Joints were assigned a numeric score reflecting anatomic location. Results-Median concentrations of substance P and prostaglandin E-2 were significantly increased in osteoarthritic joints, compared with normal joints. A significant correlation was found between concentrations of substance Pand prostaglandin E-2 in synovial fluid, but a correlation was not detected between substance P concentration in synovial fluid and anatomic locationof the joint or between radiographic scores of osteoarthritic joints and concentrations of substance P or prostaglandin E-2. Conclusions and Clinical Relevance-A correlation existed between concentrations of substance P and prostaglandin E-2 in synovial fluid obtained from normal and osteoarthritic joints. However, content of substance P in synovial fluid cannot be predicted by the radiographic appearance of the joint orits anatomic location. Substance P and prostaglandin E-2 may share an important and related role in the etiopathogenesis of osteoarthritis, lending credence to the importance of neurogenic inflammation in horses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 19:35:46