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Titolo:
Preventive effect of monoclonal antibodies to intercellular adhesion molecule-1 and leukocyte function-associate antigen-1 on murine spontaneous fetal resorption
Autore:
Takeshita, T; Satomi, M; Akira, S; Nakagawa, Y; Takahashi, H; Araki, T;
Indirizzi:
Nippon Med Sch, Dept Obstet & Gynecol, Bunkyo Ku, Tokyo 1138603, Japan Nippon Med Sch Tokyo Japan 1138603 ecol, Bunkyo Ku, Tokyo 1138603, Japan Nippon Med Sch, Dept Microbiol & Immunol, Tokyo 113, Japan Nippon Med SchTokyo Japan 113 ept Microbiol & Immunol, Tokyo 113, Japan
Titolo Testata:
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
fascicolo: 3, volume: 43, anno: 2000,
pagine: 180 - 185
SICI:
1046-7408(200003)43:3<180:PEOMAT>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATURAL-KILLER CELLS; EARLY EMBRYO LOSS; X DBA/2 MICE; SPONTANEOUS-ABORTION; CUTTING EDGE; ICAM-1; LFA-1; MACROPHAGES; TROPHOBLAST; PREGNANCY;
Keywords:
cell adhesion molecules; NK cells; spontaneous abortion; Th1 cytokine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Takeshita, T Nippon Med Sch, Dept Obstet & Gynecol, Bunkyo Ku, 1-1-5 Sendagi, Tokyo 1138603, Japan Nippon Med Sch 1-1-5 Sendagi Tokyo Japan 1138603 8603, Japan
Citazione:
T. Takeshita et al., "Preventive effect of monoclonal antibodies to intercellular adhesion molecule-1 and leukocyte function-associate antigen-1 on murine spontaneous fetal resorption", AM J REPROD, 43(3), 2000, pp. 180-185

Abstract

PROBLEM: Are cell adhesion molecules involved in the murine model of immunologically-mediated spontaneous abortion? METHOD OF STUDY: Pregnant CBA/J female mice mated with DBA/2 male mice were injected with monoclonal antibodies (MAbs) to intercellular adhesion molecule-1 (ICAM-1) and leukocyte function-associate antigen-1 (LFA-I). On day 13 of gestation, viable and resorbed embryos were counted. Natural killer (NK) cell activity in the spleen, mixed lymphocyte reactions (MLR), mixed lymphocyte-placenta reactions (MLPR), and levels of interferon (IFN)-gamma were assayed. RESULTS: Significant suppression of fetal resorption was observed by the injection of MAb to ICAM-1 and LFA-1. NK cell activity and the MLR anti-(CBA/J x DBA/2)F1 were reduced in the antibody-treated CBA/J spleen. Moreover, the level of IFN-gamma was significantly lower in the MLPR supernatants from the antibody-treated group than those of the control group. CONCLUSIONS: One mechanism in the murine model of spontaneous abortion maybe through the interaction of cell adhesion molecules, which may modulate NK cell activities and cytokine production.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 19:51:47