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Titolo:
Do soluble cell adhesion molecules play a role in endometriosis?
Autore:
Daniel, Y; Geva, E; Amit, A; Eshed-Englender, T; Baram, A; Fait, G; Lessing, JB;
Indirizzi:
Tel Aviv Univ, Lis Matern Hosp, Tel Aviv Sourasky Med Ctr,Sackler Fac Med,Dept Obstet & Gynecol, IL-64239 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-64239 ynecol, IL-64239 Tel Aviv, Israel Tel Aviv Univ, Lis Matern Hosp, Tel Aviv Sourasky Med Ctr,Sackler Fac Med,Fertilizat Unit, IL-64239 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-64239 t Unit, IL-64239 Tel Aviv, Israel Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Dept Oncol, Cytokine Res Lab, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 es Lab, IL-69978 Tel Aviv, Israel
Titolo Testata:
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
fascicolo: 3, volume: 43, anno: 2000,
pagine: 160 - 166
SICI:
1046-7408(200003)43:3<160:DSCAMP>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIATED CYTOTOXICITY; PERITONEAL-FLUID; MENSTRUAL-CYCLE; STROMAL CELLS; E-CADHERIN; EXPRESSION; INTEGRINS; ICAM-1; WOMEN; PREECLAMPSIA;
Keywords:
endometriosis; endothelial selectin; ICAM-1; inflammation; platelet selectin; soluble cell adhesion molecules; VCAM-1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Lessing, JB Tel Aviv Univ, Lis Matern Hosp, Tel Aviv Sourasky Med Ctr,Sackler Fac Med,Dept Obstet & Gynecol, 6 Weizman St, IL-64239 Tel Aviv, Israel Tel Aviv Univ 6 Weizman St Tel Aviv Israel IL-64239 v, Israel
Citazione:
Y. Daniel et al., "Do soluble cell adhesion molecules play a role in endometriosis?", AM J REPROD, 43(3), 2000, pp. 160-166

Abstract

PROBLEM: Endometriosis is a chronic inflammatory disease associated with diverse immunologic disturbances. Cell adhesion molecules are essential for the development of immune and inflammatory reactions. This study was conducted to investigate whether or not serum and peritoneal levels of soluble cell adhesion molecules are altered in women with endometriosis. METHOD OF STUDY: The study group comprised five women with moderate-to-severe endometriosis. Eight healthy women with a normal diagnostic laparoscopyserved as controls. Serum and peritoneal fluid samples from both groups were analyzed for the soluble isoform of intercellular cell adhesion molecule-1 (sICAM-1), vascular cell adhesion molecule-1 (sVCAM-1), endothelial selectin (sES), and platelet selectin (sPS). RESULTS: Serum levels of sICAM-1 were significantly increased in women with endometriosis (median levels: 410.4 ng/mL, range: 233.9 ng/mL - 598.4 ng/ml vs. 235.7 ng/mL; range: 187.4 ng/mL - 323.7 ng/mL; P = 0.02). Although the levels of sVCAM-1, sES, and sPS in both samples were higher in the studygroup, the differences did not reach significance. CONCLUSIONS: Our results suggest a role of ICAM-1 in the pathophysiology of endometriosis. However, the role of other investigated cell adhesion molecules should be confirmed by further studies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 06:29:29