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Titolo:
Genetic polymorphism at the CLOCK gene locus and major depression
Autore:
Desan, PH; Oren, DA; Malison, R; Price, LH; Rosenbaum, J; Smoller, J; Charney, DS; Gelernter, J;
Indirizzi:
VA Connecticut Healthcare Syst, W Haven, CT USA VA Connecticut Healthcare Syst W Haven CT USA care Syst, W Haven, CT USA Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA Yale Univ New Haven CT USA iv, Sch Med, Dept Psychiat, New Haven, CT USA Connecticut Mental Hlth Ctr, New Haven, CT USA Connecticut Mental Hlth Ctr New Haven CT USA Hlth Ctr, New Haven, CT USA Brown Univ, Dept Psychiat & Human Behav, Providence, RI 02912 USA Brown Univ Providence RI USA 02912 Human Behav, Providence, RI 02912 USA Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 Psychiat, Boston, MA 02114 USA Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Med, Dept Psychiat, Boston, MA 02115 USA
Titolo Testata:
AMERICAN JOURNAL OF MEDICAL GENETICS
fascicolo: 3, volume: 96, anno: 2000,
pagine: 418 - 421
SICI:
0148-7299(20000612)96:3<418:GPATCG>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
DROSOPHILA PERIOD GENE; CIRCADIAN-RHYTHMS; WINTER DEPRESSION; SLEEP; POPULATION; PREFERENCE; VARIANT; PROTEIN; CLONING; LIGHT;
Keywords:
circadian rhythms; genetic association; single nucleotide polymorphism; behavioral genetics; CLOCK gene; affective disorders;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Gelernter, J VA CT Healthcare Syst 116A2, 950 Campbell Ave, W Haven, CT 06516 USA VA CT Healthcare Syst 116A2 950 Campbell Ave W Haven CT USA 06516
Citazione:
P.H. Desan et al., "Genetic polymorphism at the CLOCK gene locus and major depression", AM J MED G, 96(3), 2000, pp. 418-421

Abstract

Genetic analysis in both mouse and Drosophila has indicated that the product of the CLOCK gene is an essential component of a circadian rhythm timingsystem. A single nucleotide polymorphism (SNP), T3111C, in the 3' flankingregion of the human CLOCK gene has been identified. Homozygotes or heterozygotes for the 3111C allele have been reported to have higher mean scores on a measure of evening preference for activity (Vs, morning preference) than subjects homozygous for the 3111T allele, Since major depression is hypothesized to be closely linked to circadian rhythms, we explored whether thispolymorphism might be related to susceptibility to major depression. We also ascertained allele frequency in an African-American control population, to begin to evaluate population variation at this locus. CLOCK T3111C allele frequencies were determined in 280 European American (EA) subjects, 143 with a history of major depression and 137 screened controls, and in 58 African American (AA) screened control subjects, using a polymerase chain reaction (PCR) - restriction fragment length polymorphism (RFLP) method. There was no significant difference between EA depressed and control subjects in allele frequency. There was a significant difference in allele frequency between EA and AA subjects, demonstrating a potential for population stratification. In none of these groups were significant deviations from Hardy-Weinberg equilibrium found. The present data do not support an association between CLOCK gene alleles at the T3111C locus and major depression. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:418-421, 2000. Published 2000 Wiley-Liss, Inc.dagger

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Documento generato il 22/01/20 alle ore 18:29:47