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Titolo:
Functional variant in the DRD2 receptor promoter region and subtypes of alcoholism
Autore:
Parsian, A; Cloninger, CR; Zhang, ZH;
Indirizzi:
Univ Louisville, Hlth Sci Ctr, Dept Mol & Cellular Biol, Louisville, KY 40202 USA Univ Louisville Louisville KY USA 40202 ar Biol, Louisville, KY 40202 USA Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA WashingtonUniv St Louis MO USA 63110 pt Psychiat, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 Dept Genet, St Louis, MO 63110 USA
Titolo Testata:
AMERICAN JOURNAL OF MEDICAL GENETICS
fascicolo: 3, volume: 96, anno: 2000,
pagine: 407 - 411
SICI:
0148-7299(20000612)96:3<407:FVITDR>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOPAMINE D2 RECEPTOR; STRUCTURAL POLYMORPHISM; LINKAGE DISEQUILIBRIA; ALLELIC ASSOCIATION; NO ASSOCIATION; GENE DRD2; SCHIZOPHRENIA; FREQUENCIES; POPULATION; LOCUS;
Keywords:
dopamine D2 receptor; functional variation; alcoholism; association;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Parsian, A Univ Louisville, Hlth Sci Ctr, Dept Mol & Cellular Biol, 501 S Preston St,Rm 301, Louisville, KY 40202 USA Univ Louisville 501 S Preston St,Rm 301 Louisville KY USA 40202
Citazione:
A. Parsian et al., "Functional variant in the DRD2 receptor promoter region and subtypes of alcoholism", AM J MED G, 96(3), 2000, pp. 407-411

Abstract

Dopaminergic pathway genes are considered as candidate genes for several neuropsychiatric diseases including severe alcoholism. Since 1990, there have been numerous reports of conflicting association studies of the Tag I A allele of the dopamine D2 receptor (DRD2) gene and alcoholism. Functional and structural variations in candidate genes offer more direct evaluation of their role in the development of a disorder. To determine the role of such variations in the DRD2 gene in the development of alcoholism subtypes, we screened a sample of 173 alcoholics and 88 normal controls with the A-241G and -141C Ins/Del variations in the promotor region and C311G variation in exon 7 of the DRD2 gene. Comparison of alcoholics with normal controls for allele frequency differences of these three variations was negative. Allele frequency differences of the two variations in the promoter region between type II alcoholics, alcoholics with medical complications, and normal controls were not significant. There was linkage disequilibrium only between -141 Ins/Del and Tag I D polymorphisms. We conclude that the functional and structural variations in DRD2 gene do not play a major role in the development of alcoholism subtypes in our sample. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:407-411, 2000. (C) 2000 Wiley-Liss, Inc.

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Documento generato il 26/01/20 alle ore 10:49:16