Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Novel HLA-B*15 alleles identified in potential marrow donors
Autore:
Williams, TM; Wu, J; Bassinger, S; Montoya, GD; Yee, J; Griffith, BB; Kearns, J; McKeen, M; Birkos, S; Gourley, IS; Kamoun, M;
Indirizzi:
Univ New Mexico, Dept Pathol, Albuquerque, NM 87131 USA Univ New Mexico Albuquerque NM USA 87131 athol, Albuquerque, NM 87131 USA Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 & Lab Med, Philadelphia, PA 19104 USA
Titolo Testata:
TISSUE ANTIGENS
fascicolo: 5, volume: 55, anno: 2000,
pagine: 455 - 459
SICI:
0001-2815(200005)55:5<455:NHAIIP>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
HLA;
Keywords:
HLA-B; DNA sequencing; bone marrow transplantation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Williams, TM Univ New Mexico, Dept Pathol, Room 337-BRF, Albuquerque, NM 87131 USA Univ New Mexico Room 337-BRF Albuquerque NM USA 87131 131 USA
Citazione:
T.M. Williams et al., "Novel HLA-B*15 alleles identified in potential marrow donors", TISSUE ANTI, 55(5), 2000, pp. 455-459

Abstract

Several methods for low-resolution class I typing of potential bone marrowdonors are available. The National Marrow Donor Program(R) (NMDP) has initiated pilot projects for large-scale DNA-based class I typing to initially characterize donors. Sequence-specific oligonucleotide probe hybridization and sequence-specific primer polymerase chain reaction (PCR) screening of 3,500 NMDP potential donors suggested the presence of variants of known HLA-B*15 variants in 3 donors. PCR products encompassing HLA-B locus exons 1 through 3 were prepared and subcloned. Sequencing revealed 3 alleles differing from known HLA-B*15 alleles by nucleotide substitutions resulting in predicted novel HLA-B antigens. The new alleles occur in distinct ethnic groups. These findings further illustrate the substantial genetic variation present at the HLA-B locus within human populations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 09:06:15