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Titolo:
Hepatic colon cancer metastases in mice: Dynamic in vivo correlation with hypoechoic rims visible at US
Autore:
Kruskal, JB; Thomas, P; Nasser, I; Cay, O; Kane, RA;
Indirizzi:
Beth Israel Deaconess Med Ctr W, Dept Radiol, Boston, MA 02215 USA Beth Israel Deaconess Med Ctr W Boston MA USA 02215 Boston, MA 02215 USA Beth Israel Deaconess Med Ctr W, Dept Canc Biol, Boston, MA 02215 USA BethIsrael Deaconess Med Ctr W Boston MA USA 02215 Boston, MA 02215 USA
Titolo Testata:
RADIOLOGY
fascicolo: 3, volume: 215, anno: 2000,
pagine: 852 - 857
SICI:
0033-8419(200006)215:3<852:HCCMIM>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
MALIGNANT LIVER-TUMORS; HISTOLOGIC CORRELATION; MR; HALO; DOXORUBICIN; ENHANCEMENT; DIAGNOSIS; CARCINOMA; LESIONS; RING;
Keywords:
blood, flow dynamics; colon, neoplasms; liver neoplasms, blood supply; liver neoplasms, secondary; liver neoplasms, US; ultrasound (US), comparative studies;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Kruskal, JB Beth Israel Deaconess Med Ctr W, Dept Radiol, 1 Deaconess Rd, Boston, MA 02215 USA Beth Israel Deaconess Med Ctr W 1 Deaconess Rd Boston MA USA 02215
Citazione:
J.B. Kruskal et al., "Hepatic colon cancer metastases in mice: Dynamic in vivo correlation with hypoechoic rims visible at US", RADIOLOGY, 215(3), 2000, pp. 852-857

Abstract

PURPOSE: To use videomicroscopy of tumor-bearing livers of live mice to depict tumors directly to determine the exact nature of rims seen on corresponding ultrasonographic (US) scans. MATERIALS AND METHODS: Seventy-six hepatic colorectal cancer metastases were studied in exteriorized livers of 18 mice by using intravital microscopy, US, and histologic examination of the same tumors. RESULTS: Hypoechoic rims correlated with distended sinusoidal spaces in vivo. These spaces surrounded only locally invasive tumors (mean diameter, 0.85 mm) that had obstructed the supplying terminal portal venules. These spaces, containing adherent leukocytes and tumor cells, gave rise to new tumorvasculature. Results of histologic examination of rims (portal inflammation, congested or compressed sinusoids, cell atrophy) correlated with leukocyte endothelial adherence, occluded sinusoids, and new vessel formation in vivo. CONCLUSION: Unlike results from previous studies, dynamic in vivo observations of peritumoral rims demonstrated distended sinusoidal spaces giving rise to new tumor-penetrating vessels. These sinusoids arose around locally invasive tumors and were associated with more advanced intrahepatic disease. These dynamic observations provide a pathophysiologic explanation for previous histologic correlates of peritumoral rims.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 17:15:16