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Titolo:
DISTRIBUTION OF BETA-ADRENOCEPTOR SUBTYPES IN GASTROINTESTINAL-TRACT OF NONDIABETIC AND DIABETIC BB RATS - A LONGITUDINAL-STUDY
Autore:
YU O; OUYANG A;
Indirizzi:
MILTON S HERSHEY MED CTR,DIV GASTROENTEROL,POB 850 HERSHEY PA 17033 HOSP UNIV PENN,DIV GASTROENTEROL PHILADELPHIA PA 19104
Titolo Testata:
Digestive diseases and sciences
fascicolo: 6, volume: 42, anno: 1997,
pagine: 1146 - 1153
SICI:
0163-2116(1997)42:6<1146:DOBSIG>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADRENERGIC RESPONSES; SMOOTH-MUSCLE; GUINEA-PIG; MOTILITY; COLON; AGE; AUTORADIOGRAPHY; NEUROPATHY; INHIBITION; RECEPTORS;
Keywords:
AGING; BB RAT; BETA-ADRENOCEPTORS; DIABETES MELLITUS; GASTROINTESTINAL TRACT; STOMACH; JEJUNUM; ILEUM; COLON;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
O. Yu e A. Ouyang, "DISTRIBUTION OF BETA-ADRENOCEPTOR SUBTYPES IN GASTROINTESTINAL-TRACT OF NONDIABETIC AND DIABETIC BB RATS - A LONGITUDINAL-STUDY", Digestive diseases and sciences, 42(6), 1997, pp. 1146-1153

Abstract

The effects of aging and diabetes on the distribution of beta-adrenoceptor subtypes in the gut were investigated in the BE rat, [I-125]Cyanopindolol binding to 10-mu m sections was evaluated using film autoradiography, Cyanopindolol binding to beta-, beta(1)-, and beta(2)-adrenoceptors was displaced by 1 mu M propranolol, 50 nhl ICI-89-406, and 100 nM ICI-118-551, respectively. beta-Adrenoceptor binding was highest in the circular muscle of proximal colon and lowest in the pylorus of 4- to 5-month-old rats. Aging (8- to 10-month-old vs, 4- to 5-month-old rats) was associated with increased beta-adrenoceptor binding in thepylorus and reduced binding in the proximal colon. Diabetes had a time-dependent effect on the level of beta-adrenoceptor binding. It was increased in the antral and pyloric stomach but longer periods of diabetes caused a reduction in beta-adrenoceptor binding in the pylorus. Those in the intestine were reduced time-dependently and involved beta(1)- or beta(2)-adrenoceptors or both.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 11:10:39