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Titolo:
ANTISECRETORY MECHANISMS OF PEPTIDE YY IN RAT DISTAL COLON
Autore:
WHANG EE; HINES OJ; REEVE JR; GRANDT D; MOSER JA; BILCHIK AJ; ZINNER MJ; MCFADDEN DW; ASHLEY SW;
Indirizzi:
BRIGHAM SURG GRP,110 CYPRESS ST BROOKLINE MA 02146 UNIV CALIF LOS ANGELES,SCH MED,DEPT SURG LOS ANGELES CA 90024 UNIV CALIF LOS ANGELES,SCH MED,DEPT MED LOS ANGELES CA 90024 BRIGHAM & WOMENS HOSP,DEPT SURG BOSTON MA 02115
Titolo Testata:
Digestive diseases and sciences
fascicolo: 6, volume: 42, anno: 1997,
pagine: 1121 - 1127
SICI:
0163-2116(1997)42:6<1121:AMOPYI>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROPEPTIDE-Y; ION-TRANSPORT; STRUCTURAL CHARACTERIZATION; ELECTROLYTE TRANSPORT; JEJUNUM MUCOSA; RECEPTORS; RABBIT; SECRETION; CANINE; BASAL;
Keywords:
PEPTIDE YY; NEUROPEPTIDE Y; COLON; INTESTINAL SECRETION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
E.E. Whang et al., "ANTISECRETORY MECHANISMS OF PEPTIDE YY IN RAT DISTAL COLON", Digestive diseases and sciences, 42(6), 1997, pp. 1121-1127

Abstract

Peptide YY (PW) is a potent regulator of intestinal secretion. These studies investigated the role of Y1 and Y2 receptor subtypes in mediating the antisecretory effects of PW on mucosa-submucosa preparations of rat distal colon. Addition of vasoactive intestinal peptide (VIP) tothese tissues resulted in a 140 +/- 18% increase in basal short-circuit current (I-SC) and the induction of Cl- secretion. VIP-stimulated increases in I-SC were abolished by the addition of each of PW, (Pro(34))-PYY, a Y1 receptor-selective agonist, and PYY-(3-36), an endogenousY2 receptor-selective ligand. However, when tissue neural transmission was blocked with tetrodotoxin, neither PW nor its receptor subtype-selective analogs were able to inhibit VIP-stimulated increases in I-SC. These results suggest that in the rat distal colon, the antisecretory actions of PW are mediated through a combination of Y1 and Y2 receptor subtypes or through a novel receptor subtype that is unable to discriminate between (Pro(34))-PYY and PYY-(3-36).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 12:33:53