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Titolo:
DISCRIMINATIVE STIMULUS EFFECTS OF ETHANOL - LACK OF ANTAGONISM WITH N-METHYL-D-ASPARTATE AND D-CYCLOSERINE
Autore:
BIENKOWSKI P; STEFANSKI R; KOSTOWSKI W;
Indirizzi:
INST PSYCHIAT & NEUROL,DEPT PHARMACOL & PHYSIOL NERVOUS SYST,AL SOBIESKIEGO 1-9 PL-02957 WARSAW POLAND INST PSYCHIAT & NEUROL,DEPT PHARMACOL & PHYSIOL NERVOUS SYST PL-02957WARSAW POLAND SCH MED,DEPT CLIN & EXPT PHARMACOL PL-00927 WARSAW POLAND
Titolo Testata:
Alcohol
fascicolo: 4, volume: 14, anno: 1997,
pagine: 345 - 350
SICI:
0741-8329(1997)14:4<345:DSEOE->2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVATED ION CURRENT; NMDA RECEPTOR; GLYCINE SITE; DRUG DISCRIMINATION; HIPPOCAMPAL-NEURONS; COGNITIVE ENHANCER; RAPID TOLERANCE; PARTIAL AGONIST; RATS; INHIBITION;
Keywords:
ETHANOL; NMDA RECEPTOR COMPLEX; D-CYCLOSERINE; DRUG DISCRIMINATION; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
P. Bienkowski et al., "DISCRIMINATIVE STIMULUS EFFECTS OF ETHANOL - LACK OF ANTAGONISM WITH N-METHYL-D-ASPARTATE AND D-CYCLOSERINE", Alcohol, 14(4), 1997, pp. 345-350

Abstract

Several drug discrimination studies reported that both competitive and uncompetitive NMDA receptor antagonists substituted for ethanol stimulus in rats. In the present study we examined if compounds that act as agonists at the NMDA receptor complex, D-cycloserine (a partial agonist al the glycine positive modulatory site) and N-methyl-D-aspartate (an agonist at the glutamate binding site), could antagonize the discriminative stimulus effects of ethanol. Rats were trained to discriminate between IP administered 1.0 g/kg of ethanol (10% v/v) and saline under a sweetened milk-reinforced fixed ratio 10 (FR10) schedule of reinforcement. When the animals met the discriminative criteria, antagonism tests were conducted with D-cycloserine (0.3-10.0 mg/kg, IP) and N-methyl-D-aspartate (15.0-60.0 mg/kg, IP). Neither D-cycloserine nor N-methyl D-aspartate antagonized the ethanol-mediated discriminative stimulus effects. In addition, D-cycloserine (3.0-300.0 mg/kg, IP) did notsubstitute for ethanol. These results indicate that at least certain agonists at the NMDA receptor complex do not attenuate the ethanol interoceptive cue in the rat. (C) 1997 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 22:03:52