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Titolo:
Lack of specific effects of selective D-1 and D-2 dopamine antagonists vs.risperidone on morphine-induced hyperactivity
Autore:
Rodriguez-Arias, M; Broseta, I; Aguilar, MA; Minarro, J;
Indirizzi:
Univ Valencia, Fac Psicol, Area Psicobiol, Valencia 46071, Spain Univ Valencia Valencia Spain 46071 Area Psicobiol, Valencia 46071, Spain
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 1, volume: 66, anno: 2000,
pagine: 189 - 197
SICI:
0091-3057(200005)66:1<189:LOSEOS>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED LOCOMOTOR-ACTIVITY; MALE-MICE; RECEPTOR ANTAGONISTS; NUCLEUS-ACCUMBENS; MOTOR-ACTIVITY; IN-VIVO; RELEASE; RATS; STIMULATION; OPIATE;
Keywords:
SCH 23390; raclopride; risperidone; hyperactivity; morphine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Minarro, J Univ Valencia, Fac Psicol, Area Psicobiol, Aptdo 22109, Valencia 46071, Spain Univ Valencia Aptdo 22109 Valencia Spain 46071 ia 46071, Spain
Citazione:
M. Rodriguez-Arias et al., "Lack of specific effects of selective D-1 and D-2 dopamine antagonists vs.risperidone on morphine-induced hyperactivity", PHARM BIO B, 66(1), 2000, pp. 189-197

Abstract

In the present study, three different dopamine antagonists were challengedin order to counteract hyperactivity induced by 50 mg/kg of morphine. A wide range of doses of morphine (50, 25, 12.5, 6.25, or 3.12 mg/kg) were evaluated on spontaneous locomotor activity. A significant increase was observed only with the two higher doses tested (25 and 50 mg/kg). No decrease was found with any of the doses used at any period of time. After analyzing doses of SCH 23390 (0.5, 0.1, and 0.05 mg/kg), raclopride (0.5, 0.25, and 0.125 mg/kg) and risperidone (0.1, 0.05, and 0.025 mg/kg) administered alone, only the 0.5 mg/kg dose of SCH 23390 decreased locomotor activity. The threecompounds counteracted morphine-induced hyperactivity, but with SCH 23390 it was only achieved with the dose of 0.5 mg/kg, which also decreased spontaneous locomotor activity and induced catalepsy. On the other hand, raclopride and risperidone neutralized morphine-induced hyperactivity at doses that did not affect locomotor activity, although the former induced catalepsy when administered with morphine. It is concluded that although the blockadeof D-1 and D-2 DA receptors decreases morphine-induced hyperactivity, thisaction is not specific, contrary to the action of risperidone, which-counteracts this hyperactivity without any other motor effects. (C) 2000 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:58:35