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Titolo:
Withdrawal symptoms in a long-term model of voluntary alcohol drinking in Wistar rats
Autore:
Holter, SM; Linthorst, ACE; Reul, JMHM; Spanagel, R;
Indirizzi:
Max Planck Inst Psychiat, D-80804 Munich, Germany Max Planck Inst Psychiat Munich Germany D-80804 D-80804 Munich, Germany
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 1, volume: 66, anno: 2000,
pagine: 143 - 151
SICI:
0091-3057(200005)66:1<143:WSIALM>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
FREE-CHOICE DRINKING; ETHANOL DEPRIVATION; BACTERIAL-ENDOTOXIN; ANIMAL-MODEL; ACAMPROSATE; DEPENDENCE; EPISODES; BEHAVIOR; STRESS; HYPERTHERMIA;
Keywords:
conditioning; ethanol; radiotelemetry; repeated alcohol deprivation; voluntary alcohol self-administration; withdrawal symptoms;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Holter, SM Max Planck Inst Psychiat, Kraepelinstr 2, D-80804 Munich, Germany Max Planck Inst Psychiat Kraepelinstr 2 Munich Germany D-80804
Citazione:
S.M. Holter et al., "Withdrawal symptoms in a long-term model of voluntary alcohol drinking in Wistar rats", PHARM BIO B, 66(1), 2000, pp. 143-151

Abstract

Long-term voluntary alcohol drinking with repeated alcohol deprivation episodes has been suggested as animal model for some aspects of alcoholism. Using a radiotelemetric system, the present study investigated the occurrenceof withdrawal symptoms in long-term voluntarily alcohol drinking Wistar rats with (repeated alcohol deprivation group) and without (first alcohol deprivation group) prior alcohol deprivation experience. Six days after transmitter implantation, alcohol bottles were removed, and returned 4 days later. Alcohol deprivation induced hyperlocomotion in both groups. In the repeated alcohol deprivation group, hyperlocomotion was increased at the beginning of the alcohol deprivation phase and decreased during the following dark phase, suggesting that removal of the alcohol bottles might have become a conditioned withdrawal stimulus for this group. Both groups showed an enhanced alcohol intake after representation of alcohol bottles compared to preabstinence intakes (alcohol deprivation effect). However, alcohol intake of the repeated alcohol deprivation group was significantly increased compared to the first alcohol deprivation group at the end of the experiment. It is concluded that repeated alcohol deprivation experience might promote the development of alcohol addiction because of its latent stimulating effect on alcohol drinking that can be unveiled by (presumably mildly stressful) experimental situations. (C) 2000 Elsevier Science Inc.

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Documento generato il 06/04/20 alle ore 04:48:09