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Titolo:
Effect of 5-HT1B receptor ligands on self-administration of ethanol in an operant procedure in rats
Autore:
Tomkins, DM; ONeill, MF;
Indirizzi:
Ctr Addict & Mental Hlth, Toronto, ON M5S 2S1, Canada Ctr Addict & Mental Hlth Toronto ON Canada M5S 2S1 to, ON M5S 2S1, Canada Univ Toronto, Dept Pharmacol, Toronto, ON, Canada Univ Toronto Toronto ONCanada onto, Dept Pharmacol, Toronto, ON, Canada Lilly Res Ctr Ltd, Surrey, England Lilly Res Ctr Ltd Surrey EnglandLilly Res Ctr Ltd, Surrey, England
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 1, volume: 66, anno: 2000,
pagine: 129 - 136
SICI:
0091-3057(200005)66:1<129:EO5RLO>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALCOHOL-DRINKING; SEROTONIN RECEPTORS; PARTIAL AGONIST; BEHAVIOR; MICE; ABUSE; CONSUMPTION; INVOLVEMENT; ANPIRTOLINE; SENSITIVITY;
Keywords:
ethanol self-administration; 5-HT1B; RU24969; CGS12066B; GR127935; saline self-administration; blood ethanol levels;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Tomkins, DM Ctr Addict & Mental Hlth, 33 Russell St, Toronto, ON M5S 2S1, Canada Ctr Addict & Mental Hlth 33 Russell St Toronto ON Canada M5S 2S1
Citazione:
D.M. Tomkins e M.F. O'Neill, "Effect of 5-HT1B receptor ligands on self-administration of ethanol in an operant procedure in rats", PHARM BIO B, 66(1), 2000, pp. 129-136

Abstract

Recent evidence suggests that 5-HT1B receptor activation modifies ethanol's reinforcing, intoxicating and discriminative stimulus effects. The present study further explored the role played by 5-HT1A/1B receptors by examining their influence on oral ethanol self-administration. Male Wistar rats were trained on an FR 4 schedule to obtain a reinforcer of 0.1 12% w/v ethanolsolution. Once responding was stable, the effect of the 5-HT1A/1B agonist RU24969 alone and in combination with the 5-HT1B antagonist GR127935 or the5-HT1A antagonists (+) WAY100135 and (+) WAY100635 was assessed. The effect of RU24969 on ethanol's pharmacokinetic profile and on operant oral saline self-administration was also examined to assess if alterations in oral ethanol self-administration were due to nonspecific effects on level pressing. For comparison, we examined the effect of another 5-HT1A/1B agonist, CGS12066B, on oral ethanol self-administration. Both RU24969 (0.1 to 1 mg/kg) and CGS12066B (0.1 to 1 mg/kg) significantly suppressed oral ethanol self-administration. Administration of GR127935 (1 mg/kg), significantly reversed the effects elicited by RU24969, whereas neither WAY100635 (1 mg/kg) nor (+)WAY100135 (1 mg/kg) had any effect. The effects of lower doses of RU24969 on oral ethanol self-administration were selective as oral saline self-administration and blood ethanol levels were not altered by these doses. These data demonstrate that 5-HT1B receptor activation suppresses oral ethanol self-administration. These studies provide further evidence that 5-HT1B receptors play a modulatory role in ethanol's behavioral effects. (C) 2000 Elsevier Science Inc.

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Documento generato il 15/08/20 alle ore 19:58:52