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Titolo:
Reinstatement of ethanol seeking in rats: Behavioral analysis
Autore:
Bienkowski, P; Koros, E; Kostowski, W; Bogucka-Bonikowska, A;
Indirizzi:
Inst Psychiat & Neurol, Dept Pharmacol, PL-02957 Warsaw, Poland Inst Psychiat & Neurol Warsaw Poland PL-02957 l, PL-02957 Warsaw, Poland Natl Ctr Sport Med, Clin Psychopharmacol Lab, PL-02034 Warsaw, Poland NatlCtr Sport Med Warsaw Poland PL-02034 l Lab, PL-02034 Warsaw, Poland Warsaw Med Univ, Dept Expt & Clin Pharmacol, PL-00927 Warsaw, Poland Warsaw Med Univ Warsaw Poland PL-00927 harmacol, PL-00927 Warsaw, Poland
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 1, volume: 66, anno: 2000,
pagine: 123 - 128
SICI:
0091-3057(200005)66:1<123:ROESIR>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
SELF-ADMINISTERED COCAINE; METHYL-D-ASPARTATE; ALCOHOL DEPENDENCE; REINFORCED BEHAVIOR; RELAPSE; EXPOSURE; FOOD; EXTINCTION; WITHDRAWAL; RECOVERY;
Keywords:
ethanol self-administration; extinction; reinstatement; relapse; craving;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Bienkowski, P Inst Psychiat & Neurol, Dept Pharmacol, Al Sobieskiego 1-9, PL-02957 Warsaw, Poland Inst Psychiat & Neurol Al Sobieskiego 1-9 Warsaw Poland PL-02957
Citazione:
P. Bienkowski et al., "Reinstatement of ethanol seeking in rats: Behavioral analysis", PHARM BIO B, 66(1), 2000, pp. 123-128

Abstract

The reinstatement model has been repeatedly used to study relapse to heroin- or cocaine-seeking behaviour in rats. The aim of the present study was to evaluate basic behavioral parameters of cue-induced reinstatement of ethanol seeking in a within-session paradigm. Rats were trained to respond for ethanol in an oral self-administration procedure where each lever press resulted in presentation of 0.3 ml of 8% ethanol from a liquid dipper. In the reinstatement paradigm operant behaviour was first extinguished for 20 or 60 min by switching the dipper off. Then, ethanol-associated stimuli were noncontingently delivered and reinstatement of responding was assessed. Deliveries of the empty dipper, i.e., visual/auditory cues only, did not result in any reinstatement. In contrast, 15 random presentations of the dipper containing either ethanol (4-8%; v/v) or water significantly reinstated ethanol seeking. In a control self-administration experiment responding dropped to nonsignificant levels when water was substituted for ethanol. The magnitude of reinstatement did not depend on the duration of the extinction phase. These results seem to indicate that in the present paradigm reinstatementof ethanol seeking is driven by a compound stimulus including the visual/auditory cues and some nonspecific sensory properties of liquid available inthe dipper. (C) 2000 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 10:00:14