Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Angiogenesis: Potentials for pharmacologic intervention in the treatment of cancer, cardiovascular diseases, and chronic inflammation
Autore:
Griffioen, AW; Molema, G;
Indirizzi:
Univ Hosp Maastricht, Dept Internal Med, Tumor Angiogenesis Lab, NL-6202 AZ Maastricht, Netherlands Univ Hosp Maastricht Maastricht Netherlands NL-6202 AZ icht, Netherlands Univ Groningen, Inst Drug Explorat, Dept Pathol & Lab Med, Tumor Immunol Lab, Groningen, Netherlands Univ Groningen Groningen Netherlands mmunol Lab, Groningen, Netherlands Univ Groningen, Dept Pharmacokinet & Drug Delivery, Groningen, NetherlandsUniv Groningen Groningen Netherlands g Delivery, Groningen, Netherlands
Titolo Testata:
PHARMACOLOGICAL REVIEWS
fascicolo: 2, volume: 52, anno: 2000,
pagine: 237 - 268
SICI:
0031-6997(200006)52:2<237:APFPII>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; VASCULAR-PERMEABILITY FACTOR; NECROSIS-FACTOR-ALPHA; MATRIX METALLOPROTEINASE INHIBITOR; RECEPTOR TYROSINE KINASES; CELL LUNG-CANCER; IN-VITRO ASSAY; SIGNAL-TRANSDUCTION PATHWAYS; INTRAMUSCULAR GENE-TRANSFER; COLLAGEN-INDUCED ARTHRITIS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
285
Recensione:
Indirizzi per estratti:
Indirizzo: Griffioen, AW Univ Hosp Maastricht, Dept Internal Med, Tumor Angiogenesis Lab, POB 5800,NL-6202 AZ Maastricht, Netherlands Univ Hosp Maastricht POB 5800 Maastricht Netherlands NL-6202 AZ
Citazione:
A.W. Griffioen e G. Molema, "Angiogenesis: Potentials for pharmacologic intervention in the treatment of cancer, cardiovascular diseases, and chronic inflammation", PHARM REV, 52(2), 2000, pp. 237-268

Abstract

Angiogenesis, or the formation of new blood vessels out of pre-existing capillaries, is a sequence of events that is fundamental to many physiologic and pathologic processes such as cancer, ischemic diseases, and chronic inflammation. With the identification of several proangiogenic molecules such as the vascular endothelial cell growth factor, the fibroblast growth factors (like in FGFs), and the angiopoietins, and the recent description of specific inhibitors of angiogenesis such as platelet factor-4, angiostatin, endostatin, and vasostatin, it is recognized that therapeutic interference with vasculature formation offers a tool for clinical applications in variouspathologies. Whereas inhibition of angiogenesis can prevent diseases with excessive vessel growth such as cancer, diabetes retinopathy, and arthritis, stimulation of angiogenesis would be beneficial in the treatment of diseases such as coronary artery disease and critical limb ischemia in diabetes. In this review we highlight the current knowledge on angiogenesis regulation and report on the recent findings in angiogenesis research and clinical studies. We also discuss the potentials, limitations, and challenges withinthis field of research, in light of the development of new therapeutic strategies for diseases in which angiogenesis plays an important role.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 18:49:29