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Titolo:
Atypical hyperplasia of choledocho-pancreatic duct epithelium in an OtsukaLong Evans Tokushima Fatty strain of rats
Autore:
Kondo, M; Kanemoto, N; Taniguchi, Y; Iwanaga, T; Arita, N; Nose, M; Tanigami, A;
Indirizzi:
Otsuka Pharmaceut Co Ltd, Otsuka GEN Res Inst, Tokushima 7710192, Japan Otsuka Pharmaceut Co Ltd Tokushima Japan 7710192 okushima 7710192, Japan Ehime Univ, Sch Med, Dept Pathol, Matsuyama, Ehime 790, Japan Ehime Univ Matsuyama Ehime Japan 790 Pathol, Matsuyama, Ehime 790, Japan
Titolo Testata:
PATHOLOGY INTERNATIONAL
fascicolo: 2, volume: 50, anno: 2000,
pagine: 126 - 135
SICI:
1320-5463(200002)50:2<126:AHOCDE>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDICAL HISTORY; K-RAS; CARCINOMA; HAMSTERS; CANCER; CARCINOGENESIS; MUTATIONS; RISK; N-NITROSOBIS(2-OXOPROPYL)AMINE; ADENOCARCINOMA;
Keywords:
diabetes; epithelial hyperplasia; pancreatic intraductal tumor; pancreatitis; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Tanigami, A Otsuka Pharmaceut Co Ltd, Otsuka GEN Res Inst, 463-10 KagasunoKawauchi Cho, Tokushima 7710192, Japan Otsuka Pharmaceut Co Ltd 463-10 Kagasuno Kawauchi Cho Tokushima Japan 7710192
Citazione:
M. Kondo et al., "Atypical hyperplasia of choledocho-pancreatic duct epithelium in an OtsukaLong Evans Tokushima Fatty strain of rats", PATHOL INT, 50(2), 2000, pp. 126-135

Abstract

Epithelial papillary hyperplasia of choledocho-pancreatic duct, associatedwith cellular atypism, was observed in Otsuka Long Evans Tokushima Fatty (OLETF) rats, a strain originally established as an animal model for non-insulin-dependent diabetes mellitus (NIDDM). To investigate the potential feasibility of OLETF rats as an animal model for pancreatic ductal carcinoma, we examined the pathological characteristics of ductal lesions in OLETF ratsaged from 5 to 50 weeks. Hyperplastic lesions in OLETF rats became apparent after 10 weeks of age and increased in severity and frequency of atypicalchanges in hyperplastic epithelium appearing after 20 weeks. We compared ductal lesions from OLETF rats with those from age-matched Long Evans Tokushima Otsuka (LETO) rats, which share a similar genetic background with OLETFrats but do not develop NIDDM, While LETO rats also display a tendency toward ductal hyperplasia, lesions from OLETF rats were more numerous and larger in size than those from age-matched LETO rats. In addition, lesions fromOLETF rats contained a significantly higher number of proliferating cell nuclear antigen-positive cells than those from LETO rats. Finally lesions inOLETF rats were accompanied by inflammation, and the observed morphological alteration of lesions correlated well with the grade of inflammation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 20:04:00