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Titolo:
Preinjury treatment with morphine or ketamine inhibits the development of experimentally induced secondary hyperalgesia in man
Autore:
Warncke, T; Stubhaug, A; Jorum, E;
Indirizzi:
Univ Oslo, Natl Hosp, Dept Neurol, N-0027 Oslo, Norway Univ Oslo Oslo Norway N-0027 Natl Hosp, Dept Neurol, N-0027 Oslo, Norway Univ Oslo, Natl Hosp, Dept Anaesthesiol, N-0027 Oslo, Norway Univ Oslo Oslo Norway N-0027 osp, Dept Anaesthesiol, N-0027 Oslo, Norway
Titolo Testata:
PAIN
fascicolo: 3, volume: 86, anno: 2000,
pagine: 293 - 303
SICI:
0304-3959(200006)86:3<293:PTWMOK>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; RAT DORSAL HORN; POSTOPERATIVE PAIN; SPINAL-CORD; CENTRAL SENSITIZATION; NEUROGENIC HYPERALGESIA; NOCICEPTIVE NEURONS; RECEPTOR ACTIVATION; ABDOMINAL-SURGERY; NEUROPATHIC PAIN;
Keywords:
hyperalgesia; wind-up; NMDA receptor antagonist; ketamine; morphine; preemptive;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Warncke, T Univ Oslo, Natl Hosp, Dept Neurol, N-0027 Oslo, Norway Univ Oslo Oslo Norway N-0027 Dept Neurol, N-0027 Oslo, Norway
Citazione:
T. Warncke et al., "Preinjury treatment with morphine or ketamine inhibits the development of experimentally induced secondary hyperalgesia in man", PAIN, 86(3), 2000, pp. 293-303

Abstract

We examine the effect of morphine or ketamine (N-methyl-D-aspartate receptor antagonist; NMDA) treatment on secondary hyperalgesia. Drug treatment started preinjury and continued into the early postinjury period. Hyperalgesia was induced by a local 1 degrees burn injury covering 12.5 cm(2) on the medial side of the calf. In this double-blind, cross-over study, 12 healthy volunteers received, on 3 separate days and in randomized order: (l)placebo; (2) morphine, bolus 150 mu g/kg + infusion 1 mu g/kg per min and 0.5 mu g/kg per min; and (3) ketamine, bolus 60 mu g/kg + infusion 6 mu g/kg per min and 3 mu g/kg per min. Bolus + infusion started 30 min before injury and ended 50 min after it. The area of secondary hyperalgesia was quantitated using punctate (von Frey filaments) and brush stimuli (electric brush). On the day of placebo, all subjects developed an area of hyperalgesia to punctate and brush stimuli outside the thermal injury (secondary hyperalgesia). We show that ketamine or morphine treatment starting preinjury significantlyreduces this development (P < 0.01,both). In a previous study, we found that postinjury treatment alone with morphine did not affect secondary hyperalgesia, whereas ketamine did so significantly. The differential response tomorphine administered pre- or postinjury may be relevant to the recently shown NMDA receptor mediated interaction of central hyperexcitability and morphine antinociception. The effect of ketamine supports the hypothesis of the role of NMDA receptor mediation in central hyperexcitability. (C) 2000 International Association for the Study of Pain. Published by Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 09:20:31