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Titolo:
Degradation of human Aurora2 protein kinase by the anaphase-promoting complex-ubiquitin-proteasome pathway
Autore:
Honda, K; Mihara, H; Kato, Y; Yamaguchi, A; Tanaka, H; Yasuda, H; Furukawa, K; Urano, T;
Indirizzi:
Nagoya Univ, Sch Med, Dept Biochem 2, Showa Ku, Nagoya, Aichi 4660065, Japan Nagoya Univ Nagoya Aichi Japan 4660065 a Ku, Nagoya, Aichi 4660065, Japan Fukui Med Sch, Dept Surg 1, Fukui 9101193, Japan Fukui Med Sch Fukui Japan 9101193 Sch, Dept Surg 1, Fukui 9101193, Japan Tokyo Univ Pharm & Life Sci, Sch Life Sci, Hachioji, Tokyo 1920392, Japan Tokyo Univ Pharm & Life Sci Hachioji Tokyo Japan 1920392 o 1920392, Japan
Titolo Testata:
ONCOGENE
fascicolo: 24, volume: 19, anno: 2000,
pagine: 2812 - 2819
SICI:
0950-9232(20000601)19:24<2812:DOHAPK>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHROMOSOME SEGREGATION; CELL-CYCLE; IN-VIVO; YEAST; PROTEOLYSIS; EXPRESSION; BINDING; IPL1; TRANSFORMATION; LOCALIZATION;
Keywords:
Aurora2; degradation; anaphase-promoting complex; ubiquitin-proteasome pathway;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Urano, T Nagoya Univ, Sch Med, Dept Biochem 2, Showa Ku, 65 Tsurumai-machi, Nagoya,Aichi 4660065, Japan Nagoya Univ 65 Tsurumai-machi Nagoya Aichi Japan 4660065 5, Japan
Citazione:
K. Honda et al., "Degradation of human Aurora2 protein kinase by the anaphase-promoting complex-ubiquitin-proteasome pathway", ONCOGENE, 19(24), 2000, pp. 2812-2819

Abstract

Human Aurora2 was originally identified by its close homology to yeast IPL1 and fly aurora, which are key regulators of chromosome segregation and a family of serine/threonine kinases, Here we demonstrate that the Aurora2 protein is degraded rapidly after G2/M phase release in mammalian cells. Aurora2 protein has a rapid turnover rate with a half-life of approximately 2 h, Tn eukaryotic cells, the ubiquitin-proteasome pathway is the major mechanism for the targeted degradation of unstable proteins, The treatment of mammalian cells with proteasome inhibitors blocks Aurora2 degradation. Furthermore, Aurora2 is polyubiquitinated in vivo and in vitro using anaphase-promoting complex (APC), These results demonstrate that Aurora2 protein is turned over through the APC-ubiquitin-proteasome pathway.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/21 alle ore 15:46:00