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Titolo:
Increased striatal dopamine transporter in adult patients with attention deficit hyperactivity disorder: effects of methylphenidate as measured by single photon emission computed tomography
Autore:
Krause, KH; Dresel, SH; Krause, J; Kung, HF; Tatsch, K;
Indirizzi:
Univ Munich, Med Klin Innenstadt, Friedrich Baur Inst, D-80336 Munich, Germany Univ Munich Munich Germany D-80336 ch Baur Inst, D-80336 Munich, Germany Univ Munich, Dept Nucl Med, D-80336 Munich, Germany Univ Munich Munich Germany D-80336 ept Nucl Med, D-80336 Munich, Germany Outpatient Clin Psychiat & Psychotherapy, D-85521 Ottobrunn, Germany Outpatient Clin Psychiat & Psychotherapy Ottobrunn Germany D-85521 rmany Univ Penn, Dept Radiol, Philadelphia, PA 19104 USA Univ Penn PhiladelphiaPA USA 19104 pt Radiol, Philadelphia, PA 19104 USA
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 2, volume: 285, anno: 2000,
pagine: 107 - 110
SICI:
0304-3940(20000512)285:2<107:ISDTIA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL GLUCOSE-METABOLISM; MAGNETIC-RESONANCE; CHILDREN; TRODAT-1; BINDING; HUMANS;
Keywords:
dopamine transporter; attention deficit hyperactivity disorder; adult; TRODAT-1; single photon emission computed tomography; methylphenidate;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Krause, KH Univ Munich, Med Klin Innenstadt, Friedrich Baur Inst, Ziemssenstr 1A, D-80336 Munich, Germany Univ Munich Ziemssenstr 1A Munich Germany D-80336 ich, Germany
Citazione:
K.H. Krause et al., "Increased striatal dopamine transporter in adult patients with attention deficit hyperactivity disorder: effects of methylphenidate as measured by single photon emission computed tomography", NEUROSCI L, 285(2), 2000, pp. 107-110

Abstract

Ten previously untreated adults with attention deficit hyperactivity disorder (ADHD) were investigated before and after 4 weeks of treatment with a dose of 3x5 mg methylphenidate/d by single photon emission computed tomography (SPECT) with [Tc-99m]TRODAT-1, the first Tc-99m labelled SPECT ligand specifically binding to the dopamine transporter (DAT). For semiquantitative evaluation of the DAT, specific binding ([STR-BKG]/BKG) was calculated in the striatum (STR) with the cerebellum used as background (BKG). The patients with ADHD presented with increased specific binding of Tc-99m-TRODAT-1 tothe DAT as compared with age and sex matched controls ([STR-BKG]/BKG 1.43 /- 0.18 vs. 1.22 +/- 0.05, P < 0.001). After treatment with methylphenidate specific binding decreased in all patients ([STR-BKG]/BKG 1.02 +/- 0.23, P < 0.001). Thus, for the first time it could be demonstrated using SPECT that methylphenidate lowers increased striatal DAT availability in adults suffering from ADHD. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 10:20:52