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Titolo:
Sleep laboratory studies in restless legs syndrome patients as compared with normals and acute effects of ropinirole 2. Findings on periodic leg movement, arousals and respiratory variables
Autore:
Saletu, M; Anderer, P; Saletu, B; Hauer, C; Mandl, M; Oberndorfer, S; Zoghlami, A; Saletu-Zyhlarz, G;
Indirizzi:
Univ Vienna, Sch Med, Dept Psychiat, Sect Sleep Res & Pharmacopsychiat, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 armacopsychiat, A-1090 Vienna, Austria
Titolo Testata:
NEUROPSYCHOBIOLOGY
fascicolo: 4, volume: 41, anno: 2000,
pagine: 190 - 199
SICI:
0302-282X(2000)41:4<190:SLSIRL>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOUBLE-BLIND; NOCTURNAL MYOCLONUS; LIMB MOVEMENTS; L-DOPA; PARKINSONS-DISEASE; CROSSOVER TRIAL; F-18 DOPA; CLONAZEPAM; PLACEBO; BROMOCRIPTINE;
Keywords:
restless legs syndrome; periodic leg movements; arousals; respiratory variables; ropinirole; acute sleep study;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Saletu, B Univ Vienna, Sch Med, Dept Psychiat, Sect Sleep Res & Pharmacopsychiat, Waehringer Guertel 18, A-1090 Vienna, Austria Univ Vienna Waehringer Guertel 18 Vienna Austria A-1090 Austria
Citazione:
M. Saletu et al., "Sleep laboratory studies in restless legs syndrome patients as compared with normals and acute effects of ropinirole 2. Findings on periodic leg movement, arousals and respiratory variables", NEUROPSYCHB, 41(4), 2000, pp. 190-199

Abstract

The restless legs syndrome (RLS) is a common sensorimotor disorder which leads to severe sleep disturbances and showed a prevalence of 7.9% in our sleep laboratory. The aim of this study was to investigate periodic leg movements (PLM), arousal and respiratory variables in 12 untreated RLS patients and to measure the acute effects of 0.5 mg ropinirole, a nonergoline dopamine agonist, as compared with placebo. in the target variable PLM/h of totalsleep time (PLM/h TST), RLS patients showed an increased value of 40/h (normal 0-5/h). Further, we found an increased number of PLM (368), PLM/h of time in bed (49/h), PLM/h of REM sleep (11), PLM/h of non-REM sleep (46) andPLM/h awake (61). The arousal index was also increased (32/h; normal 0-25/h), as were arousals due to PLM. In the confirmatory part of our descriptive data analysis, ropinirole 0.5 mg significantly improved, as compared withplacebo, the index PLM/h TST by 75%. In the descriptive part, all the other PLM variables were improved as well. Arousals due to PLM decreased, whilespontaneous arousals increased. Respiratory variables, which had a priori been in the normal range, showed a slight but significant improvement afterthe dopamine agonist. Thus, 0.5 mg ropinirole significantly improved the target variable PLM/h TST, along with objective and subjective sleep qualityand morning noopsychic performance, as described in the preceding paper. Our data encourage further sleep studies including all above-mentioned variables in a larger group of RLS/PLM during sleep patients as well as long-term efficacy trials. Copyright (C) 2000 S. Karger AG, Basel.

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Documento generato il 07/08/20 alle ore 06:27:40