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Titolo:
SNAREs contribute to the specificity of membrane fusion
Autore:
Scales, SJ; Chen, YA; Yoo, BY; Patel, SM; Doung, YC; Scheller, RH;
Indirizzi:
Stanford Univ, Sch Med, Dept Cellular & Mol Physiol, Howard Hughes Med Inst, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 ghes Med Inst, Stanford, CA 94305 USA
Titolo Testata:
NEURON
fascicolo: 2, volume: 26, anno: 2000,
pagine: 457 - 464
SICI:
0896-6273(200005)26:2<457:SCTTSO>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOPLASMIC-RETICULUM; VESICULAR TRANSPORT; SYNAPTIC EXOCYTOSIS; VESICLE TRAFFICKING; SYNTAXIN FAMILY; PROTEIN; COMPLEX; SNAP-25; CELLS; IDENTIFICATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Scheller, RH Stanford Univ, Sch Med, Dept Cellular & Mol Physiol, Howard Hughes Med Inst, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305, Stanford, CA 94305 USA
Citazione:
S.J. Scales et al., "SNAREs contribute to the specificity of membrane fusion", NEURON, 26(2), 2000, pp. 457-464

Abstract

Intracellular membrane fusion is mediated by the formation of a four-helixbundle comprised of SNARE proteins. Every cell expresses a large number ofSNARE proteins that are localized to particular membrane compartments, suggesting that the fidelity of vesicle trafficking might in part be determined by specific SNARE pairing. However, the promiscuity of SNARE pairing in vitro suggests that the information for membrane compartment organization isnot encoded in the inherent ability of SNAREs to form complexes. Here, we show that exocytosis of norepinephrine from PC12 cells is only inhibited orrescued by specific SNAREs. The data suggest that SNARE pairing does underlie vesicle trafficking fidelity, and that specific SNARE interactions withother proteins may facilitate the correct pairing.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/21 alle ore 17:28:42