Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The effect of fentanyl, DNQX and MK-801 on dorsal horn neurones responsiveto colorectal distension in the anaesthetized rat
Autore:
Kozlowski, CM; Bountra, C; Grundy, D;
Indirizzi:
Glaxo Wellcome Res & Dev Ltd, Neurosci Unit, Stevenage SG1 2NY, Herts, England Glaxo Wellcome Res & Dev Ltd Stevenage Herts England SG1 2NY rts, England Univ Sheffield, Dept Biomed Sci, Sheffield S10 2TN, S Yorkshire, England Univ Sheffield Sheffield S Yorkshire England S10 2TN S Yorkshire, England
Titolo Testata:
NEUROGASTROENTEROLOGY AND MOTILITY
fascicolo: 3, volume: 12, anno: 2000,
pagine: 239 - 247
SICI:
1350-1925(200006)12:3<239:TEOFDA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
SACRAL SPINAL-CORD; NMDA RECEPTOR ANTAGONIST; VISCERAL PAIN; NOCICEPTIVE TRANSMISSION; PREGANGLIONIC NEURONS; HYPERALGESIA; MORPHINE; REFLEX; NERVE; MECHANISMS;
Keywords:
colorectal distension; DNQX; dorsal horn neurones; fentanyl; MK-801;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Kozlowski, CM Glaxo Wellcome Res & Dev Ltd, Neurosci Unit, Stevenage SG1 2NY, Herts, England Glaxo Wellcome Res & Dev Ltd Stevenage Herts England SG1 2NY
Citazione:
C.M. Kozlowski et al., "The effect of fentanyl, DNQX and MK-801 on dorsal horn neurones responsiveto colorectal distension in the anaesthetized rat", NEUROG MOT, 12(3), 2000, pp. 239-247

Abstract

Certain dorsal horn neurones respond in a graded manner to noxious colorectal distension (CRD). Morphine inhibits these responses in the spinalized rat, but the role of excitatory amino acids in baseline visceral nociceptivetransmission is less clear. This study examines the effect of the mu-opiate receptor agonist fentanyl, and the non-NMDA and NMDA antagonists DNQX andMK-801, respectively, on such responses to CRD in the sodium pentobarbitone-anaesthetized rat. Male rats were prepared for extracellular recording from the lumbosacral spinal cord. 90 neurones responsive to CRD, located throughout the dorsal horn, were classified according to their response duration and latency to 60 mmHg distension, as SL-A (short latency-abrupt; 59%), SL-S (short latency-sustained; 23%), L-L (long-latency; 10%) and Inhib (inhibited; 8%). Convergent cutaneous receptive fields were mapped for 79/90 neurones and classifiedas LT (low threshold), WDR (wide dynamic range) or HT (high threshold). CRD (20-100 mm Hg) elicited graded responses in most neurones. In 6/6 SL-S neurones, fentanyl (1-8 mu g kg(-1)) dose-dependently inhibited the response to 60 mm Hg CRD, in a naloxone-sensitive manner, with an ID50 value (+/- 95% confidence limits) of 2.48 (1.7-3.7) mu g kg(-1). In 6/6 SL-A neurones, fentanyl had no significant effect on the response to CRD. DNQX (0.03-3 mg kg(-1)) produced a dose-dependent inhibition of the response to CRD in 5/5 SL-A neurones, with an ID50 value of 0.32 (0.01-41.1) mg kg(-1). MK-801 (0.03-0.3 mg kg(-1)) had no significant effect on responses to CRD in 6/6 SL-A neurones. The differential inhibitory effects of fentanyl on two neuronal subtypes may indicate functional differences. In SL-A neurones AMPA/kainate, but not NMDA receptors are involved in mediating baseline nociceptive neurotransmission.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 06:37:51