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Titolo:
Dial 9-1-1 for p53: Mechanisms of p53 activation by cellular stress
Autore:
Ljungman, M;
Indirizzi:
Univ Michigan, Ctr Comprehens Canc, Dept Radiat Oncol, Div Canc Biol,Program Cellular & Mol Biol, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MIUSA 48109 & Mol Biol, Ann Arbor, MI 48109 USA
Titolo Testata:
NEOPLASIA
fascicolo: 3, volume: 2, anno: 2000,
pagine: 208 - 225
SICI:
1522-8002(200005/06)2:3<208:D9FPMO>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
WILD-TYPE P53; TUMOR-SUPPRESSOR PROTEIN; DNA-DEPENDENT PROTEIN; RNA-POLYMERASE-II; ATAXIA-TELANGIECTASIA CELLS; NUCLEOTIDE EXCISION-REPAIR; TATA-BINDING PROTEIN; CASEIN KINASE-II; DAMAGE-INDUCED PHOSPHORYLATION; TRANSCRIPTIONALLY ACTIVE P53;
Keywords:
phosphorylation; blocked RNA polymerase II; nucleocytoplasmic shuttling; MDM2; proteasome;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
290
Recensione:
Indirizzi per estratti:
Indirizzo: Ljungman, M Univ Michigan, Ctr Comprehens Canc, Dept Radiat Oncol, Div Canc Biol,Program Cellular & Mol Biol, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 Ann Arbor, MI 48109 USA
Citazione:
M. Ljungman, "Dial 9-1-1 for p53: Mechanisms of p53 activation by cellular stress", NEOPLASIA, 2(3), 2000, pp. 208-225

Abstract

The tumor suppressor protein, p53, is part of the cell's emergency team that is called upon following cellular insult. How do cells sense DNA damage and other cellular stresses and what signal transduction pathways are used to alert p53? How is the resulting nuclear accumulation of p53 accomplishedand what determines the outcome of p53 induction? Many posttranslational modifications of p53, such as phosphorylation, dephosphorylation, acetylation and ribosylation, have been shown to occur following cellular stress. Some of these modifications may activate the p53 protein, interfere with MDM2 binding and/or dictate cellular localization of p53, This review will focuson recent findings about how the p53 response may be activated following cellular stress.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/10/20 alle ore 14:21:47