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Titolo:
Frequent interspecific genetic exchange between commensal neisseriae and Neisseria meningitidis
Autore:
Linz, B; Schenker, M; Zhu, PX; Achtman, M;
Indirizzi:
Max Planck Inst Mol Genet, D-14195 Berlin, Germany Max Planck Inst Mol Genet Berlin Germany D-14195 D-14195 Berlin, Germany
Titolo Testata:
MOLECULAR MICROBIOLOGY
fascicolo: 5, volume: 36, anno: 2000,
pagine: 1049 - 1058
SICI:
0950-382X(200006)36:5<1049:FIGEBC>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
OUTER-MEMBRANE PROTEIN; MOLECULAR EVOLUTION; ESCHERICHIA-COLI; SEROGROUP-A; PENICILLIN RESISTANCE; INTERGENERIC TRANSFER; HELICOBACTER-PYLORI; CHROMOSOMAL GENES; RECOMBINATION; COMPLEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Achtman, M Max Planck Inst Mol Genet, Ihnestr 73, D-14195 Berlin, Germany Max Planck Inst Mol Genet Ihnestr 73 Berlin Germany D-14195 ny
Citazione:
B. Linz et al., "Frequent interspecific genetic exchange between commensal neisseriae and Neisseria meningitidis", MOL MICROB, 36(5), 2000, pp. 1049-1058

Abstract

Natural sequence variation was investigated among serogroup A subgroup IV-1 Neisseria meningitidis isolated from diseased patients and healthy carriers in The Gambia, West Africa. The frequencies of DNA import were analysed by sequencing fragments of four linked genes encoding the immunogenic outermembrane proteins TbpB (transferrin binding protein B) and OpaA (an adhesin) plus two housekeeping enzymes. Seventeen foreign tbpB alleles were independently imported into the 98 strains tested, apparently due to immune selection. The median size of the imported DNA fragments was 5 kb, resulting inthe occasional concurrent import of linked housekeeping genes by hitchhiking. Sequences of tbpB from other strains of N. meningitidis as well as commensal Neisseria lactamica and Neisseria spp. isolated from the same geographical area revealed that these species share a common tbpB gene pool and identified several examples of interspecific genetic exchange. These observations indicate that recombination can be more frequent between related species than within a species and indicate that effective vaccination against serogroup B meningococcal disease may be difficult to achieve.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 09:51:24