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Titolo:
Activation of neurokinin NK2 receptors by tachykinin peptides causes contraction of uterus in pregnant women near term
Autore:
Patak, EN; Ziccone, S; Story, ME; Fleming, AJ; Lilley, A; Pennefather, JN;
Indirizzi:
Monash Univ, Dept Pharmacol, Clayton, Vic 3800, Australia Monash Univ Clayton Vic Australia 3800 acol, Clayton, Vic 3800, Australia Monash Univ, Dept Pharmacol, Clayton, Vic 3168, Australia Monash Univ Clayton Vic Australia 3168 acol, Clayton, Vic 3168, Australia Royal Womens Hosp, Dept Anaesthet, Carlton, Vic 3053, Australia Royal Womens Hosp Carlton Vic Australia 3053 Carlton, Vic 3053, Australia
Titolo Testata:
MOLECULAR HUMAN REPRODUCTION
fascicolo: 6, volume: 6, anno: 2000,
pagine: 549 - 554
SICI:
1360-9947(200006)6:6<549:AONNRB>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANGIOTENSIN-CONVERTING ENZYME; GUINEA-PIG UTERUS; ESTROGEN-PRIMED RAT; SUBSTANCE-P; AMINOPEPTIDASE-N; NEUTRAL ENDOPEPTIDASE; MAMMALIAN TACHYKININS; PLASMA EXTRAVASATION; SELECTIVE AGONISTS; SYNAPTIC-MEMBRANES;
Keywords:
human uterus; NK2 receptors; peptidase inhibitors; pregnancy; tachykinins;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Story, ME Monash Univ, Dept Pharmacol, Clayton, Vic 3800, Australia MonashUniv Clayton Vic Australia 3800 ton, Vic 3800, Australia
Citazione:
E.N. Patak et al., "Activation of neurokinin NK2 receptors by tachykinin peptides causes contraction of uterus in pregnant women near term", MOL HUM REP, 6(6), 2000, pp. 549-554

Abstract

The aim of this study was firstly to elucidate whether the mammalian tachykinins substance P (SP), neurokinin A (NKA) and neurokinin B (NKB)-regutated contractility of myometrium obtained from near-term pregnant women, and secondly to investigate the receptor subtype(s) responsible. In the presenceof peptidase inhibitors, i.e. thiorphan (3 mu mol/l; endopeptidase 24.11 inhibitor), captopril (10 mu mol/l; angiotensin converting enzyme inhibitor)and bestatin (10 mu mol/l; aminopeptidase inhibitor); all three mammalian tachykinins elicited concentration-related contractions of isolated myometrial preparations. The rank order of agonist potency of the mammalian tachykinins in the presence of the peptidase inhibitors was NKA > SP = NKB, indicating that the contractile effects were mediated by activation of an NK2 receptor. The NK2 receptor-selective agonist, [Lys(5), MeLeu(9), Nle(10)]NKA(4-10), produced concentration-related contractile responses, while the respective NK1 and NK3 receptor-selective agonists, [Sar(9),Met(O-2)(11)]SP and[N-MePhe(7)]NKB, had no effect either in the absence or presence of the peptidase inhibitors. The NK, receptor-selective antagonist, SR48968, produced concentration-related rightward shift in the log concentration curve to [Lys(5), MeLeu(9), Nle(10)]NKA(4-10). This study shows that tachykinins elicit contractile effects on human myometrium obtained from pregnant women near term, and that these effects are mediated by an NK2 receptor. An excitatory effect of the tachykinins on these preparations could indicate a physiological role for these peptides in enhancing contractility of the uterus in women at term.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 04:54:36