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Titolo:
G proteins mediate changes in cell shape by stabilizing the axis of polarity
Autore:
Nern, A; Arkowitz, RA;
Indirizzi:
MRC, Mol Biol Lab, Div Cell Biol, Cambridge CB2 2QH, England MRC Cambridge England CB2 2QH Div Cell Biol, Cambridge CB2 2QH, England
Titolo Testata:
MOLECULAR CELL
fascicolo: 5, volume: 5, anno: 2000,
pagine: 853 - 864
SICI:
1097-2765(200005)5:5<853:GPMCIC>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
BUD-SITE SELECTION; GTP-EXCHANGE FACTOR; SACCHAROMYCES-CEREVISIAE; BUDDING YEAST; ACTIN CYTOSKELETON; GENE-PRODUCT; LOCALIZATION; PATHWAY; SEPTIN; MORPHOGENESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Arkowitz, RA MRC, Mol Biol Lab, Div Cell Biol, Hills Rd, Cambridge CB2 2QH, England MRC Hills Rd Cambridge England CB2 2QH idge CB2 2QH, England
Citazione:
A. Nern e R.A. Arkowitz, "G proteins mediate changes in cell shape by stabilizing the axis of polarity", MOL CELL, 5(5), 2000, pp. 853-864

Abstract

Upon exposure to mating pheromone, yeast cells change their form to pear-shaped shmoos. We looked at pheromone-dependent cell shape changes in mutants that are unable to orient growth during mating and unable to choose a budsite. In these double mutants, cell surface growth, secretion sites, cytoskeleton, and pheromone receptors are spread out, explaining why these cellsare round. In contrast, polarity establishment proteins localize to discrete sites in these mutants. However, the location of these sites wanders. Thus, these mutants are able to initiate polarized growth but fail to maintain the location of growth sites. Our results demonstrate that stabilization of the growth axis requires positional signaling from either the pheromone receptor or specific bud site selection proteins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 04:38:34