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Titolo:
Isolation and characterization of a new subtype of Borna disease virus
Autore:
Nowotny, N; Kolodziejek, J; Jehle, CO; Suchy, A; Staeheli, P; Schwemmle, M;
Indirizzi:
Univ Vet Sci Vienna, Inst Virol, A-1210 Vienna, Austria Univ Vet Sci Vienna Vienna Austria A-1210 Virol, A-1210 Vienna, Austria Univ Vet Sci Vienna, Inst Pathol & Forens Vet Med, A-1210 Vienna, Austria Univ Vet Sci Vienna Vienna Austria A-1210 et Med, A-1210 Vienna, Austria Univ Freiburg, Dept Virol, D-79008 Freiburg, Germany Univ Freiburg Freiburg Germany D-79008 Virol, D-79008 Freiburg, Germany
Titolo Testata:
JOURNAL OF VIROLOGY
fascicolo: 12, volume: 74, anno: 2000,
pagine: 5655 - 5658
SICI:
0022-538X(200006)74:12<5655:IACOAN>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
PSYCHIATRIC-PATIENTS; NEUROPSYCHIATRIC DISORDERS; SEQUENCE CONSERVATION; MOOD DISORDERS; ANTIBODIES; RNA; BLOOD; SCHIZOPHRENIA; ORGANIZATION; PROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Nowotny, N Univ Vet Sci Vienna, Inst Virol, Vet Pl 1, A-1210 Vienna, Austria Univ Vet Sci Vienna Vet Pl 1 Vienna Austria A-1210 na, Austria
Citazione:
N. Nowotny et al., "Isolation and characterization of a new subtype of Borna disease virus", J VIROLOGY, 74(12), 2000, pp. 5655-5658

Abstract

Borna disease virus (BDV), the causative agent of severe meningoencephalitis in a wide variety of animal species, has been considered to be genetically invariable and to form a single type within the genus Bornavirus of the family Bornaviridae, BDV infections are of particular interest, because forthe first time a virus infection appears to be linked to human psychiatricdisorders. We now describe a new subtype of BDV isolated from a horse which was euthanatized due to severe, incurable neurological disease. The nucleotide sequence of this new strain, named No/98, differs from the reference strains by more than 15%, and the subtype is difficult to detect by standard reverse transcriptase PCR protocols, The nucleotide exchanges of the novel BDV isolate have surprisingly little effect on the primary structures of most viral proteins, with the notable exception of the X protein (p10), which is only 81% identical to its counterpart in reference strains. Our data indicate that the genome of BDV is far more variable than previously assumed and that naturally occurring subtypes may escape detection by currently used diagnostic assays.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 15:35:28