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Titolo:
Prevalence of primary resistance to zidovudine and lamivudine in drug-naive human immunodeficiency virus type-1 infected patients: High proportion ofreverse transcriptase codon 215 mutant in circulating lymphocytes and freevirus
Autore:
Trabaud, MA; Leriche-Guerin, K; Regis, C; Bordes, I; Cotte, L; Detmer, J; Kolberg, J; Ritter, J; Trepo, C;
Indirizzi:
Fac Pharm Lyon, Lab Hyg & Immunol, F-69008 Lyon, France Fac Pharm Lyon Lyon France F-69008 b Hyg & Immunol, F-69008 Lyon, France INSERM U271, Lyon, France INSERM U271 Lyon FranceINSERM U271, Lyon, France Hop Hotel Dieu, Dept Hepatogastroenterol, F-69288 Lyon, France Hop Hotel Dieu Lyon France F-69288 togastroenterol, F-69288 Lyon, France Bayer Diagnost, Emeryville, CA USA Bayer Diagnost Emeryville CA USABayer Diagnost, Emeryville, CA USA
Titolo Testata:
JOURNAL OF MEDICAL VIROLOGY
fascicolo: 3, volume: 61, anno: 2000,
pagine: 352 - 359
SICI:
0146-6615(200007)61:3<352:POPRTZ>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSMISSION; HIV-1; MUTATIONS; EVOLUTION;
Keywords:
differential hybridization; proviral DNA; transmission; drug-resistance mutations; T215Y/F; M184V;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Trabaud, MA Fac Pharm Lyon, Lab Hyg & Immunol, 8 Ave Rockefeller, F-69008 Lyon, France Fac Pharm Lyon 8 Ave Rockefeller Lyon France F-69008 , France
Citazione:
M.A. Trabaud et al., "Prevalence of primary resistance to zidovudine and lamivudine in drug-naive human immunodeficiency virus type-1 infected patients: High proportion ofreverse transcriptase codon 215 mutant in circulating lymphocytes and freevirus", J MED VIROL, 61(3), 2000, pp. 352-359

Abstract

The presence of primary zidovudine (AZT)resistance (mutation T215Y/F) or lamivudine (3TC)-resistance (mutation M184V) was evaluated in 90 drug-naive patients infected with human immunodeficiency virus type-1 (HIV-1) between 1987 and 1997. The proportion of mutant strains in proviral samples or plasma viral samples was determined using a differential hybridization assay. Mutation T215Y/F was found in five (5.6%) patients infected between 1994 and1997, whereas none of these patients harbored the mutation M184V. The T215Y/F mutation was present in the virus and/or provirus and persisted for at least two years. In one patient, the mutant provirus was associated with only wildtype free virus. Four of these patients were followed, and two were treated subsequently to a regimen containing AZT but with low response. Thepersistence of primary resistance mutations might depend on the proportionof these mutations at the time of infection, although mutant provirus might not give rise to replicating variants. (C) 2000 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 06:08:35