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Titolo:
Human herpesvirus 8-encoded interleukin-6 homologue (viral IL-6) induces endogenous human IL-6 secretion
Autore:
Mori, Y; Nishimoto, N; Ohno, M; Inagi, R; Dhepakson, P; Amou, K; Yoshizaki, K; Yamanishi, K;
Indirizzi:
Osaka Univ, Sch Med, Dept Microbiol, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 crobiol, Suita, Osaka 5650871, Japan Osaka Univ, Sch Hlth & Sport Sci, Dept Med Sci 1, Osaka, Japan Osaka UnivOsaka Japan h Hlth & Sport Sci, Dept Med Sci 1, Osaka, Japan
Titolo Testata:
JOURNAL OF MEDICAL VIROLOGY
fascicolo: 3, volume: 61, anno: 2000,
pagine: 332 - 335
SICI:
0146-6615(200007)61:3<332:HH8IH(>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULTICENTRIC CASTLEMANS-DISEASE; KAPOSIS-SARCOMA; DNA-SEQUENCES; EXPRESSION; CYTOKINE; ENCODES; CELLS; KSHV;
Keywords:
human herpesvirus-8; viral IL-6; human IL-6; induction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Mori, Y Osaka Univ, Sch Med, Dept Microbiol, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan Osaka Univ 2-2 Yamadaoka Suita Osaka Japan 5650871 5650871, Japan
Citazione:
Y. Mori et al., "Human herpesvirus 8-encoded interleukin-6 homologue (viral IL-6) induces endogenous human IL-6 secretion", J MED VIROL, 61(3), 2000, pp. 332-335

Abstract

We found that human herpesvirus 8-encoded IL-6 (vIL-6) induced endogenous human IL-6 (huIL-6) secretion from various cell lines (MT-4, THP-1, U937, Raji, and CESS) including patients with multicentric Castleman's disease. Especially, in MT-4 cells, huIL-6 was enhanced with vIL-6 by 30-fold comparedwith that of control. In addition, reverse transcriptase-polymerase chain reaction confirmed that vIL-6 induced huIL-6 expression in MT-4 cells. Our novel finding of the huIL-6 induction by vIL-6 indicates that vIL-6 may play a significant role in the pathogenesis of HHV-8 associated diseases. (C) 2000 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 13:54:28