Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Dopamine: a role in the pathogenesis and treatment of hypertension
Autore:
Murphy, MB;
Indirizzi:
Natl Univ Ireland, Dept Pharmacol & Therapeut, Cork, Ireland Natl Univ Ireland Cork Ireland ept Pharmacol & Therapeut, Cork, Ireland
Titolo Testata:
JOURNAL OF HUMAN HYPERTENSION
, volume: 14, anno: 2000, supplemento:, 1
pagine: S47 - S50
SICI:
0950-9240(200004)14:<S47:DARITP>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRAVENOUS FENOLDOPAM; RECEPTOR; AGONIST; NITROPRUSSIDE; PRESSURE;
Keywords:
dopamine; blood pressure; hypertension;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Murphy, MB Cork Univ Hosp, Dept Pharmacol & Therapeut, Clin Sci Bldg, Wilton, Cork, Ireland Cork Univ Hosp Clin Sci Bldg Wilton Cork Ireland Cork, Ireland
Citazione:
M.B. Murphy, "Dopamine: a role in the pathogenesis and treatment of hypertension", J HUM HYPER, 14, 2000, pp. S47-S50

Abstract

The catecholamine dopamine (DA), activates two distinct classes of DA-specific receptors in the cardiovascular system and kidney-each capable of influencing systemic blood pressure. D-1 receptors on vascular smooth muscle cells mediate vasodilation, while on renal tubular cells they modulate sodiumexcretion. D-2 receptors on pre-synaptic nerve terminals influence noradrenaline release and, consequently, heart rate and vascular resistance. Activation of both, by low dose DA lowers blood pressure. While DA also binds toalpha- and beta-adrenoceptors, selective agonists at both DA receptor classes have been studied in the treatment of hypertension. An unfavourable side-effect profile (largely nausea and orthostasis) have precluded wide use of D-2 agonists. In contrast, the D-1 selective agonist fenoldopam has been licensed for the parenteral treatment of severe hypertension. Apart from inducing systemic vasodilation it induces a diuresis and natriuresis, enhanced renal blood flow, and a small increment in glomerular filtration rate. Evidence is emerging that abnormalities in DA production, or in signal transduction of the D-1 receptor in renal proximal tubules, may result in salt retention and high blood pressure in some humans and in several animal modelsof hypertension.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 08:10:46