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Titolo:
Role of bradykinins and nitric oxide in the AT(2) receptor-mediated hypotension
Autore:
Sosa-Canache, B; Cierco, M; Gutierrez, CI; Israel, A;
Indirizzi:
Univ Centroccidental Lisandro Alvarado, Sch Med, Clin Pharmacol Unit, Barquisimeto, Venezuela Univ Centroccidental Lisandro Alvarado Barquisimeto Venezuela Venezuela
Titolo Testata:
JOURNAL OF HUMAN HYPERTENSION
, volume: 14, anno: 2000, supplemento:, 1
pagine: S40 - S46
SICI:
0950-9240(200004)14:<S40:ROBANO>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANGIOTENSIN AT(1) RECEPTOR; SYMPATHETIC-NERVE FUNCTION; NUCLEUS-TRACTUS-SOLITARII; RAT-BRAIN; VASOPRESSIN RELEASE; BLOOD-PRESSURE; CONSCIOUS RATS; II ANTAGONISM; MICE LACKING; SYSTEM;
Keywords:
angiotensin AT(2) receptor; losartan; PD 123319; kinins; nitric oxide synthase; footshocks;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Israel, A Apartado Postal 50176,Sabana Grande 1050, Caracas, Venezuela Apartado Postal 50176,Sabana Grande 1050 Caracas Venezuela la
Citazione:
B. Sosa-Canache et al., "Role of bradykinins and nitric oxide in the AT(2) receptor-mediated hypotension", J HUM HYPER, 14, 2000, pp. S40-S46

Abstract

Footshocks increases mean arterial pressure and heart rate. Systemic or intracerebroventricular (IVT) administration of losartan, a specific angiotensin AT(1) receptor antagonist, not only inhibited the presser response to footshocks but resulted in vasodepression. Peripheral or IVT administration of PD 123319, a specific angiotensin AT(2) receptor antagonist, did not alter the haemodynamic response to footshocks. However, simultaneous blockade of angiotensin AT(1) and AT(2) receptors by combined systemic or central administration of losartan and PD 12319, eliminated the vasodepressor response to footshocks unmasked in losartan pretreated rats. Our data suggest thatactivation of peripheral or brain angiotensin AT(2) receptor mediated the vasodepressor response to footshocks in the presence of angiotensin AT(1) receptor antagonist. We studied the role of kinins and nitric oxide in the vasodepressor response observed after footshocks. The decrease in mean arterial pressure observed after footshocks in losartan treated rats was bluntedby systemic or IVT administration of icatibant (HOE 140) or N-G-nitro-L-arginine-methyl ester, indicating that peripheral or brain kinins and nitric oxide are involved in the hypotensor response to footshocks during angiotensin AT(1) receptor blockade. Our results suggest a role for angiotensin AT(2) receptor in the regulation of arterial blood pressure, possibly through the release of vasodilator autacoids such as bradykinins and nitric oxide.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 16:05:06