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Titolo:
Correlation between docetaxel clearance and estimated cytochrome P450 activity by urinary metabolite of exogenous cortisol
Autore:
Yamamoto, N; Tamura, T; Kamiya, Y; Sekine, I; Kunitoh, H; Saijo, N;
Indirizzi:
Natl Canc Ctr Hosp, Div Internal Med, Chuo Ku, Tokyo 1040045, Japan Natl Canc Ctr Hosp Tokyo Japan 1040045 ed, Chuo Ku, Tokyo 1040045, Japan
Titolo Testata:
JOURNAL OF CLINICAL ONCOLOGY
fascicolo: 11, volume: 18, anno: 2000,
pagine: 2301 - 2308
SICI:
0732-183X(200006)18:11<2301:CBDCAE>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
ERYTHROMYCIN BREATH TEST; PHASE-II TRIAL; PERFORMANCE LIQUID-CHROMATOGRAPHY; CELL LUNG-CANCER; INTRAVENOUS-INFUSION; ANTHRACYCLINE-RESISTANT; CYP3A ACTIVITY; 6-BETA-HYDROXYCORTISOL; TAXOTERE; POPULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Tamura, T Natl Canc Ctr Hosp, Div Internal Med, Chuo Ku, 1-1 Tsukiji 5 chome, Tokyo 1040045, Japan Natl Canc Ctr Hosp 1-1 Tsukiji 5 chome Tokyo Japan 1040045 apan
Citazione:
N. Yamamoto et al., "Correlation between docetaxel clearance and estimated cytochrome P450 activity by urinary metabolite of exogenous cortisol", J CL ONCOL, 18(11), 2000, pp. 2301-2308

Abstract

Purpose: There is no simple and practical method for the estimation of theinterpatient variability of cytochrome P450 (CYP3A4) enzyme activity. Cortisol is metabolized by this enzyme and excreted as 6-beta-hydroxycortisol (6 beta-OHF) and free-cortisol (FC) in urine, and docetaxel is also metabolized by hepatic CYP3A4 enzyme. We developed a new method for the estimation of CYP3A4 activity by measuring urinary cortisol metabolite after administration of exogenous cortisol. This study was aimed at assessing the predictability of the individual activity of CYP3A4 estimated by this method. Patients and Methods: Thirty patients with advanced non-small-cell lung cancer were entered onto this study. Hydrocortisone 300 mg was administered intravenously, and urinary 6 beta-OHF and FC were measured, More than 2 dayslater, 60 mg/m(2) of docetaxel was administered intravenously with pharmacokinetic sampling. The correlation between docetaxel pharmacokinetics and estimated interpatient variability of CYP3A4 activity with the application of our method was assessed,Results: After cortisol administration, the total amount of 24-hour urinary 6 beta-OHF (T6 beta-OHF) increased about 60-fold compared with pretreatment levels, averaging 12,273 +/- 4,076 mu g/d (mean +/- SD). Docetaxel clearance (CL) and area under the concentration-time curve averaged 24.5 +/- 6.4L/h/m(2) and 2.66 +/- 0.91 mg/L 8729 h, respectively. An excellent correlation between docetaxel CL and T6 beta-OHF was observed (r = .867). In multivariate analysis, T6 beta-OHF (P < .001), alpha-1-acid glycoprotein (P < .004), AST (P = .007), and age (P = .022) significantly correlated with docetaxel CL. Conclusion: The interpatient variability of CYP3A4 activity and docetaxel CL could be predicted by measuring T6 beta-OHF after cortisol administration. J Clin Oncol 18:2301-2308. (C) 2000 by American Society of Clinical Oncology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 14:54:17