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Titolo:
Weak androgen levels, glucocorticoid therapy, and bone mineral density in postmenopausal women with rheumatoid arthritis
Autore:
Fiter, J; Nolla, JM; Navarro, MA; Gomez-Vaquero, C; Rosel, P; Mateo, L; Roig-Escofet, D;
Indirizzi:
Ciutat Sanitaria Univ Bellvitge, Princeps Espanya Hosp, Dept Rheumatol, Barcelona, Spain Ciutat Sanitaria Univ Bellvitge Barcelona Spain matol, Barcelona, Spain Ciutat Sanitaria Univ Bellvitge, Princeps Espanya Hosp, Hormone Lab, Barcelona, Spain Ciutat Sanitaria Univ Bellvitge Barcelona Spain e Lab, Barcelona, Spain
Titolo Testata:
JOINT BONE SPINE
fascicolo: 3, volume: 67, anno: 2000,
pagine: 199 - 203
SICI:
1297-319X(200001)67:3<199:WALGTA>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEX-HORMONE STATUS; DEHYDROEPIANDROSTERONE-SULFATE; SERUM DEHYDROEPIANDROSTERONE; ADRENAL ANDROGEN; ASSOCIATION; AXIS;
Keywords:
androstenedione; bone mineral density; dehydroepiandrosterone sulfate; rheumatoid arthritis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Fiter, J Manso 17,6 5A, Barcelona 08015, Spain Manso 17,6 5A Barcelona Spain 08015 5A, Barcelona 08015, Spain
Citazione:
J. Fiter et al., "Weak androgen levels, glucocorticoid therapy, and bone mineral density in postmenopausal women with rheumatoid arthritis", JOINT BONE, 67(3), 2000, pp. 199-203

Abstract

Objective. To study dehydroepiandrosterone sulfate (DHEAS) and androstenedione (AND) status in postmenopausal women with rheumatoid arthritis (RA), the effects of glucocorticoid therapy on DHEAS and AND levels, and their relationship with bone mineral density (BMD). Methods. Forty-six postmenopausal women with RA were separated into two groups based on whether they had a negative history for glucocorticoid therapy (n = 24) or were currently on glucocorticoid therapy (n = 22). The control group was composed of 39 postmenopausal women who had never received hormone replacement therapy. Serum DHEAS and AND levels were measured using a radioimmunoassay. BMD was determined at the lumbar spine (L2-L4) and femoral neck using a DEXA Hologic QDR-1000 densitometer. Results, RA patients and controls were similar in age, weight, body mass index, and years since menopause. DHEAS and AND levels were lower in the glucocorticoid-treated RA group than in the other two groups. The glucocorticoid-treated RA group also had a significantly lower femoral BMD value than the nonglucocorticoid-treated RA group. Lumbar BMD was similar in the two RA groups and in the controls. Conclusion. Decreases in DHEASand AND levels in postmenopausal women with RA are probably related to glucocorticoid therapy rather than to the disease itself. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

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Documento generato il 02/04/20 alle ore 00:18:49