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Titolo:
Rational and "irrational" design of proteins and their use in biotechnology
Autore:
Nixon, AE; Firestine, SM;
Indirizzi:
Dyax Corp, Cambridge, MA 02139 USA Dyax Corp Cambridge MA USA 02139Dyax Corp, Cambridge, MA 02139 USA Penn State Univ, Dept Chem, University Pk, PA 16802 USA Penn State Univ University Pk PA USA 16802 m, University Pk, PA 16802 USA
Titolo Testata:
IUBMB LIFE
fascicolo: 3, volume: 49, anno: 2000,
pagine: 181 - 187
SICI:
1521-6543(200003)49:3<181:RA"DOP>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
INORGANIC-PHOSPHATE RELEASE; GREEN FLUORESCENT PROTEINS; IN-VITRO RECOMBINATION; DIRECTED EVOLUTION; MOLECULAR EVOLUTION; CANCER-THERAPY; THYMIDINE KINASE; INCREMENTAL TRUNCATION; GENERIC BIOSENSORS; RANDOM MUTAGENESIS;
Keywords:
combinatorial; DNA shuffling; protein engineering; rational design;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
72
Recensione:
Indirizzi per estratti:
Indirizzo: Nixon, AE Dyax Corp, 1 Kendall Sq,Bldg 600,5th Floor, Cambridge, MA 02139 USA Dyax Corp 1 Kendall Sq,Bldg 600,5th Floor Cambridge MA USA 02139
Citazione:
A.E. Nixon e S.M. Firestine, "Rational and "irrational" design of proteins and their use in biotechnology", IUBMB LIFE, 49(3), 2000, pp. 181-187

Abstract

A familiar refrain within industrial circles is better, faster, and cheaper. Efforts to place this mantra into practice within the biotechnology industry has brought a focus on protein engineering as one method to create newproducts quickly and inexpensively. Typically, protein engineering has utilized either rational design or combinatorial methods, both of which have been explored and improved in recent years. Continued advancement in these two areas and their application to an increasing list of industrially and medically important processes mean that the number of "synthetic" proteins displacing old technologies is likely to grow at an amazing rate over the next few years. We discuss some of the technologies available for protein redesign and illustrate these with examples from the biocatalysis, biosensor, and therapeutic fields.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:39:00