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Titolo:
Characterization of desmosomal component expression during palatogenesis
Autore:
Mogass, M; Bringas, P; Shuler, CF;
Indirizzi:
Univ So Calif, Ctr Craniofacial Mol Biol, Los Angeles, CA 90033 USA Univ So Calif Los Angeles CA USA 90033 ol Biol, Los Angeles, CA 90033 USA
Titolo Testata:
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
fascicolo: 3, volume: 44, anno: 2000,
pagine: 317 - 322
SICI:
0214-6282(200004)44:3<317:CODCED>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
PALATE DEVELOPMENT; CELL-ADHESION; DESMOCOLLIN; CADHERINS; DIFFERENTIATION; TISSUES; BOVINE; IDENTIFICATION; DESMOGLEIN; PATTERNS;
Keywords:
desmosome; palate development;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Shuler, CF Univ So Calif, Ctr Craniofacial Mol Biol, 2250 Alcazar St CSA103, Los Angeles, CA 90033 USA Univ So Calif 2250 Alcazar St CSA103 Los Angeles CA USA 90033 A
Citazione:
M. Mogass et al., "Characterization of desmosomal component expression during palatogenesis", INT J DEV B, 44(3), 2000, pp. 317-322

Abstract

Adhesion of the opposing palatal shelves is a critical first step in the mechanism for palatal fusion. Formation of desmosomal junctions between the two medial edge epithelia provides a mechanism for palatal shelf adhesion, RT-PCR and immunohistochemistry were used to determine the pattern of expression of desmosomal components during palatogenesis. Desmosomal expression was specifically upregulated in the medial edge epithelia (MEE) at the early stages of palatal fusion as detected by both immunohistochemistry and electron microscopy. RT-PCR characterization of the desmosomal components detected all known elements, except desmocollin 1 (DSC1), Desmocollin 2 (DSC2) was expressed as both the DSC2a and DSC2b variants. The two variants are expressed at the same level. Western analysis of desmoglein expression paralleled the RT-PCR result. The temporal and spatial upregulation of desmosomalgene expression is evidence that the MEE induce new gene expression required to accomplish palatal shelf adhesion and initiate the first stage of palatal fusion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 09:19:16