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Titolo:
The Tcf17 gene at chromosome 5q is not involved in the development of conventional renal cell carcinoma
Autore:
Bugert, P; Pesti, T; Kovacs, G;
Indirizzi:
Univ Heidelberg, Dept Urol, Oncol Mol Lab, D-69120 Heidelberg, Germany Univ Heidelberg Heidelberg Germany D-69120 , D-69120 Heidelberg, Germany
Titolo Testata:
INTERNATIONAL JOURNAL OF CANCER
fascicolo: 6, volume: 86, anno: 2000,
pagine: 806 - 810
SICI:
0020-7136(20000615)86:6<806:TTGAC5>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSCRIPTION FACTOR; MICROSATELLITE ANALYSIS; TUMORS; DUPLICATION; KID-1; EXPRESSION; REGIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Kovacs, G Univ Heidelberg, Dept Urol, Oncol Mol Lab, Neuenheimer Feld 365,D-69120 Heidelberg, Germany Univ Heidelberg Neuenheimer Feld 365 Heidelberg Germany D-69120
Citazione:
P. Bugert et al., "The Tcf17 gene at chromosome 5q is not involved in the development of conventional renal cell carcinoma", INT J CANC, 86(6), 2000, pp. 806-810

Abstract

The human Kid-1 homolog Tcf17 has been cloned and assigned to chromosome 5q35.3. Since the chromosome 5q22-qter region is duplicated in approximately50% of conventional renal-cell carcinomas, it was suggested that Tcf17 is involved in the development of renal tumors. We have analyzed Tcf17 mRNA innormal kidneys and genetically distinct types of renal-cell tumor and found it expressed in nearly all normal kidney and tumor samples. There was no correlation between allelic duplication and expression of Tcf17. We did notfind mutations within the coding sequences but did detect deletions withinthe zinc finger domain in a small proportion of RNA molecules in both normal and tumor tissues. We found ubiquitous expression of human Tcf17 as wellas rat Kid-1 in different types of human and rat tissue, indicating that the putative transcription-regulating activity of this zinc finger gene, in contrast to the published data, is not restricted to the kidney. The results of expression and mutation analyses suggest that the Tcf17 gene is not involved in the development of renal-cell tumors. (C) 2000 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 14:36:24