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Titolo:
Modulation of hyperoxia-induced TNF-alpha expression in the newborn rat lung by thalidomide and dexamethasone
Autore:
Lindsay, L; Oliver, SJ; Freeman, SL; Josien, R; Krauss, A; Kaplan, G;
Indirizzi:
New York Hosp, Cornell Med Ctr, Dept Neonatol, New York, NY 10021 USA New York Hosp New York NY USA 10021 Dept Neonatol, New York, NY 10021 USA Rockefeller Univ, Cellular Physiol & Immunol Lab, New York, NY 10021 USA Rockefeller Univ New York NY USA 10021 mmunol Lab, New York, NY 10021 USA
Titolo Testata:
INFLAMMATION
fascicolo: 4, volume: 24, anno: 2000,
pagine: 347 - 356
SICI:
0360-3997(200008)24:4<347:MOHTEI>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; BRONCHOPULMONARY DYSPLASIA; ENDOTHELIAL PERMEABILITY; TOXICITY; MACROPHAGES; ACTIVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Lindsay, L New York Hosp, Cornell Med Ctr, Dept Neonatol, New York, NY 10021 USA New York Hosp New York NY USA 10021 ol, New York, NY 10021 USA
Citazione:
L. Lindsay et al., "Modulation of hyperoxia-induced TNF-alpha expression in the newborn rat lung by thalidomide and dexamethasone", INFLAMMATIO, 24(4), 2000, pp. 347-356

Abstract

The effect of high oxygen concentrations on lungs of neonatal rats was studied. In addition, some oxygen-exposed animals were treated with either dexamethasone or thalidomide. No gross histologic changes were noted in the lungs following exposure to 95% oxygen nor were there changes in the total number or the phenotypic distribution of BAL cells obtained from these lungs compared to lungs from air exposed (control) neonatal rats. The majority ofthe BAL cells were CD45+ leukocytes (macrophages). However, when BAL cellswere exposed to LPS in vitro, TNF-alpha production was higher in cells from rats exposed to 95% oxygen compared to cells from rats exposed to ambientair. In addition, lung TNF-alpha and IL-6 mRNA levels were increased afterexposure to 95% oxygen. In the lungs of animals treated with either dexamethasone or thalidomide, TNF-alpha mRNA levels were reduced, while only dexamethasone treatment also reduced IL-6 mRNA levels.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 14:40:02