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Titolo:
Age-related association of MHC class I chain-related gene A (MICA) with type 1 (insulin-dependent) diabetes mellitus
Autore:
Kawabata, Y; Ikegami, H; Kawaguchi, Y; Fujisawa, T; Hotta, M; Ueda, H; Shintani, M; Nojima, K; Ono, M; Nishino, M; Taniguchi, H; Noso, S; Yamada, K; Babaya, N; Ogihara, T;
Indirizzi:
Osaka Univ, Sch Med, Dept Geriatr Med, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 atr Med, Suita, Osaka 5650871, Japan
Titolo Testata:
HUMAN IMMUNOLOGY
fascicolo: 6, volume: 61, anno: 2000,
pagine: 624 - 629
SICI:
0198-8859(200006)61:6<624:AAOMCI>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATURAL-KILLER-CELLS; HLA; SUSCEPTIBILITY; IDDM; HETEROGENEITY; CYTOTOXICITY; ALLELES; DISEASE; REGION; NKG2D;
Keywords:
type 1 (insulin-dependent) diabetes mellitus; susceptibility; age-at-onset; human leukocyte antigen (HLA); MHC class I chain-related gene A (MICA);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Ikegami, H Osaka Univ, Sch Med, Dept Geriatr Med, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan Osaka Univ 2-2 Yamadaoka Suita Osaka Japan 5650871 50871, Japan
Citazione:
Y. Kawabata et al., "Age-related association of MHC class I chain-related gene A (MICA) with type 1 (insulin-dependent) diabetes mellitus", HUMAN IMMUN, 61(6), 2000, pp. 624-629

Abstract

To assess the contribution of the HLA class I region to susceptibility to and heterogeneity of type 1 diabetes, we investigated the association of polymorphism of MHC class I chain-related gene A (MICA) with age-at-onset as well as susceptibility to type 1 diabetes. One hundred one Japanese patients and 110 healthy control subjects were studied. The frequency of A4 allelewas significantly higher and that of AG allele was significantly lower in patients than in control subjects. The frequency of A5.1 allele was highestin early-onset patients (23.0%), intermediate in intermediate-onset patients (9.2%) and lowest in late-onset patients (7.7%) (trend chi-squared test,p = 0.0098). A5.1 allele was strongly associated with HLA-B7 and Cw7, suggesting that MICA*A5.1-B7-Cw7 haplotype contains a gene responsible for age-at-onset. A4 allele was associated with a susceptible haplotype, DR4-DQB1*0401, and AG allele was associated with a protective haplotype, DR2-DQB1*0601, suggesting that the association of MICA with type 1 diabetes susceptibility may be due to linkage disequilibrium with class II haplotypes. These data suggest that MICA gene is associated with age-at-onset and that a gene (or genes) responsible fur age-at-onset of type 1 diabetes is located in theHLA class I region, probably near the region of MICA-B-C. (C) American Society for Histocompatibility and Immunogenetics, 2000. Published by ElsevierScience Inc.

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Documento generato il 19/09/20 alle ore 21:40:25