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Titolo:
Clinical usefulness of urine-based enzyme-linked immunosorbent assay for detection of antibody to Helicobacter pylori: A collaborative study in nine medical institutions in Japan
Autore:
Kato, M; Asaka, M; Saito, M; Sekine, H; Ohara, S; Toyota, T; Akamatsu, T; Kaneko, T; Kiyosawa, K; Nishizawa, O; Kumagai, T; Katsuyama, T; Abe, M; Kosaka, M; Hariya, S; Minami, K; Sanai, Y; Sawamura, M; Tachikawa, T;
Indirizzi:
Hokkaido Univ, Sch Med, Dept Internal Med 3, Sapporo, Hokkaido 060, Japan Hokkaido Univ Sapporo Hokkaido Japan 060 3, Sapporo, Hokkaido 060, Japan Sapporo Hokuyu Hosp, Dept Digest Tract Med, Sapporo, Hokkaido, Japan Sapporo Hokuyu Hosp Sapporo Hokkaido Japan Med, Sapporo, Hokkaido, Japan Tohoku Univ, Sch Med, Dept Internal Med 3, Sendai, Miyagi 980, Japan Tohoku Univ Sendai Miyagi Japan 980 rnal Med 3, Sendai, Miyagi 980, Japan Shinshu Univ, Sch Med, Endoscopy Unit, Matsumoto, Nagano, Japan Shinshu Univ Matsumoto Nagano Japan scopy Unit, Matsumoto, Nagano, Japan Shinshu Univ, Sch Med, Dept Internal Med 2, Matsumoto, Nagano, Japan Shinshu Univ Matsumoto Nagano Japan rnal Med 2, Matsumoto, Nagano, Japan Shinshu Univ, Sch Med, Dept Urol, Matsumoto, Nagano, Japan Shinshu Univ Matsumoto Nagano Japan Dept Urol, Matsumoto, Nagano, Japan Shinshu Univ, Sch Med, Clin Lab, Matsumoto, Nagano, Japan Shinshu Univ Matsumoto Nagano Japan , Clin Lab, Matsumoto, Nagano, Japan Univ Tokushima, Sch Med, Dept Internal Med 1, Tokushima 770, Japan Univ Tokushima Tokushima Japan 770 Internal Med 1, Tokushima 770, Japan Hokkaido Prefectural Fac Examinat Ctr, Sapporo, Hokkaido, Japan Hokkaido Prefectural Fac Examinat Ctr Sapporo Hokkaido Japan aido, Japan Sapporo Toho Hosp, Dept Obstet & Gynecol, Sapporo, Hokkaido, Japan SapporoToho Hosp Sapporo Hokkaido Japan necol, Sapporo, Hokkaido, Japan Keiai Hosp, Dept Obstet & Gynecol, Obihiro, Hokkaido, Japan Keiai Hosp Obihiro Hokkaido Japan et & Gynecol, Obihiro, Hokkaido, Japan Shinjuku Sakura Urol Clin, Tokyo, Japan Shinjuku Sakura Urol Clin Tokyo Japan ku Sakura Urol Clin, Tokyo, Japan Otsuka Pharmaceut Co Ltd, Dept Diagnost Reagents, Tokushima 7710192, JapanOtsuka Pharmaceut Co Ltd Tokushima Japan 7710192 okushima 7710192, Japan
Titolo Testata:
HELICOBACTER
fascicolo: 2, volume: 5, anno: 2000,
pagine: 109 - 119
SICI:
1083-4389(200006)5:2<109:CUOUEI>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
CAMPYLOBACTER-PYLORI; DYSPEPTIC PATIENTS; IMMUNOGLOBULIN-G; BREATH TEST; INFECTION; DIAGNOSIS; GASTRITIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Tachikawa, T Otsuka Pharmaceut Co Ltd, Dept Diagnost Reagents, 463-10 Kagasuno KawauchiCho, Tokushima 7710192, Japan Otsuka Pharmaceut Co Ltd 463-10 Kagasuno Kawauchi Cho Tokushima Japan 7710192
Citazione:
M. Kato et al., "Clinical usefulness of urine-based enzyme-linked immunosorbent assay for detection of antibody to Helicobacter pylori: A collaborative study in nine medical institutions in Japan", HELICOBACT, 5(2), 2000, pp. 109-119

Abstract

Background, A urine-based enzyme-linked immunosorbent assay (ELISA) kit for detection of antibody to Helicobacter pylori has been developed in Japan. Urine samples can be obtained noninvasively and are easier and safer to handle than are serum samples, The aim of this study was to examine the clinical usefulness of this urine-based ELISA kit. Materials and Methods, A pair of random, single-void urine and serum samples was collected from each of 1,061 subjects, including 238 patients with gastroduodenal disease. The sensitivity and specificity of the urine-based ELISA was compared with those of three commercially available serum-based ELISA kits. For those patients with gastroduodenal disease, the urine- and serum-based ELISA results were also compared with these for other diagnostic methods using endoscopic biopsy specimens, such as culture, histology, and rapid urease tests,Results. Based on the three serum-based ELISA results, the sensitivity, specificity, and accuracy of the urine-based ELISA were 97.7%, 95.6%, and 96.8%, respectively. On the basis of the biopsy test results, the sensitivity (96.2%), specificity (78.9%), and accuracy (91.0%) of the urine-based ELISAwere almost equivalent or superior to all three serum-based ELISAs tested. In addition, 10 of the 12 false-positive cases for urine-based ELISA were confirmed to be true positives for antibodies to H. pylori by Western blot analysis and inhibition ELISA,Conclusions. The urine-based ELISA (URINELISA H. pylori Antibody) is very accurate and should be useful as an alternative to serum-based ELISAs for screening of H. pylori infection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 09:38:06