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Titolo:
Intrascleral concentration vs depth profile of mitomycin-C after episcleral application: Impact of applied concentration and volume of mitomycin-C solution
Autore:
Vass, C; Georgopoulos, M; El Menyawi, I; Radda, S; Nimmerrichter, P;
Indirizzi:
Univ Vienna, Dept Ophthalmol, Vienna, Austria Univ Vienna Vienna Austria niv Vienna, Dept Ophthalmol, Vienna, Austria Univ Vienna, Dept Internal Med, Vienna, Austria Univ Vienna Vienna Austria v Vienna, Dept Internal Med, Vienna, Austria
Titolo Testata:
EXPERIMENTAL EYE RESEARCH
fascicolo: 5, volume: 70, anno: 2000,
pagine: 571 - 575
SICI:
0014-4835(200005)70:5<571:ICVDPO>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLAUCOMA FILTERING SURGERY; AQUEOUS-HUMOR FLOW; EXTRAOCULAR APPLICATION; ADJUNCTIVE MITOMYCIN; LONG-TERM; POSTOPERATIVE 5-FLUOROURACIL; INTRAOPERATIVE MITOMYCIN; TRABECULECTOMY SURGERY; CILIARY BODY; RABBITS;
Keywords:
glaucoma; mitomycin-C; concentration; filtering surgery; complication; toxicity; ciliary body;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Vass, C Univ Vienna, Dept Ophthalmol, Vienna, Austria Univ Vienna ViennaAustria na, Dept Ophthalmol, Vienna, Austria
Citazione:
C. Vass et al., "Intrascleral concentration vs depth profile of mitomycin-C after episcleral application: Impact of applied concentration and volume of mitomycin-C solution", EXP EYE RES, 70(5), 2000, pp. 571-575

Abstract

The purpose of this study was to investigate the impact of different concentrations and volumes of Mitomycin-C (MMC) on the intrascleral concentration vs depth profile of MMC in an experimental model. The episcleral sides ofscleral quadrants of human donor eyes were exposed for 1 min to sponges (corneal light shield, Merocel Corp.) soaked with MMC. After irrigation with 40 ml saline a central 8 mm diameter scleral disk was horizontally dissected with a cryotome. MMC concentrations of six layers of 140 mu m thickness were analysed by means of high-performance liquid chromatography. In Experiment 1 (11 eyes) the sponges were soaked with 50 mu l of 10, 100 and 200 mu g ml(-1) MMC solutions. In Experiment 2 (12 eyes) the sponges were soaked With 10, 30, 50 and 80 mu l of a 200 mu g ml(-1) isotonic MMC solution. In Experiment 1 the MMC concentrations (mu g g(-1)) of layer 1 were 0.35 (/- 0.20; 10 mu g ml(-1) group) and 9.22 (+/- 2.92; 200 mu g ml(-1) group). In Experiment 2 the MMC concentrations were 2.57 (+/- 1.17; 10 mu l group), 7.35 (+/- 2.49; 30 mu l group) and 11.67 (+/- 3.25; 80 mu l group). The scleral MMC concentrations were significantly influenced by the applied concentrations (layers 1-5) and by the applied volumes (all layers) of MMC solution. The intrascleral MMC concentration increased linearly with increasing concentration and not linearly with increasing Volume of the applied MMC solution. To achieve more predictable scleral concentrations of MMC after trabeculectomy with MMC it seems advisable to control both the concentration and the volume of the MMC solution used to soak the sponge. (C) 2000 Academic Press.

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Documento generato il 27/11/20 alle ore 13:36:47