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Titolo:
Discrepancy between Gleason scores of biopsy and radical prostatectomy specimens
Autore:
Koksal, IT; Ozcan, F; Kadioglu, TC; Esen, T; Kilicaslan, I; Tunc, M;
Indirizzi:
Istanbul Univ, Fac Med, Dept Urol, Istanbul, Turkey Istanbul Univ Istanbul Turkey niv, Fac Med, Dept Urol, Istanbul, Turkey Istanbul Univ, Fac Med, Dept Pathol, Istanbul, Turkey Istanbul Univ Istanbul Turkey v, Fac Med, Dept Pathol, Istanbul, Turkey
Titolo Testata:
EUROPEAN UROLOGY
fascicolo: 6, volume: 37, anno: 2000,
pagine: 670 - 674
SICI:
0302-2838(200006)37:6<670:DBGSOB>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
FINAL PATHOLOGICAL DIAGNOSIS; PROSTATIC NEEDLE BIOPSIES; TUMOR GRADE; CANCER; CARCINOMA; ACCURACY; PREDICTION; ANTIGEN; DISEASE; STAGE;
Keywords:
prostate carcinoma; needle biopsy; radical prostatectomy; Gleason score;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Koksal, IT Serifkuyu Sokak Koksal Apt 33-6, TR-81170 Uskudar Istanbul, Turkey Serifkuyu Sokak Koksal Apt 33-6 Uskudar Istanbul Turkey TR-81170
Citazione:
I.T. Koksal et al., "Discrepancy between Gleason scores of biopsy and radical prostatectomy specimens", EUR UROL, 37(6), 2000, pp. 670-674

Abstract

Objective: The grade of the prostate cancer is an important factor in defining prognosis and deciding on treatment. In this study, we compared the Gleason score determined by 18-gauge core needle biopsies with both the Gleason score and pathological staging of the radical prostatectomy specimens. Patients and Methods: Between July 1992 and September 1998, we performed 144radical retropubic prostatectomies for clinically localized prostatic carcinoma, after a negative frozen section in bilateral pelvic lymphadenectomy in all cases. Ten patients with pathologic stage T1a and T1b were excluded. The final study group consisted of 134 patients, all of whom had been diagnosed with adenocarcinoma by transrectal needle biopsies with an 18-gauge automated spring-loaded biopsy gun. No patients received neoadjuvant therapy, including androgen deprivation and radiation therapy. All patients had a designated Gleason score on the needle biopsy and prostatectomy specimens. Results: We found that grading error was greatest with well-differentiated (Gleason score 2-4) tumors. The accuracy was 15% for Gleason score 2-4 on needle biopsy. Of the 113 evaluable patients with Gleason score 5-7 on needle biopsy, 110 (97%) were graded correctly. All of the Gleason score 8-10 onneedle biopsy was graded correctly. But only 1 patient in our series had Gleason score 8 on needle biopsy. Twenty-seven (25%) of 110 patients with a biopsy grade of Gleason score <7 had the cancer upgraded to 7. Of patients with both Gleason score <7 in the needle biopsy and Gleason score 7 in the prostatectomy specimen, only 3 (11%) had tumor confined to the prostate. Conclusion: The potential for grading error is greatest with well-differentiated tumors and of patients with both Gleason scores <7 in the needle biopsyand Gleason score 7 in the prostatectomy specimen, only 11% had tumor confined to the prostate. This effects treatment policy, especially for watchful waiting criteria. Copyright (C) 2000 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 06:48:50