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Titolo:
Suppression of serum gonadal steroids in rats by chronic treatment with dopamine and serotonin reuptake inhibitors
Autore:
Rehavi, M; Attali, G; Gil-Ad, I; Weizman, A;
Indirizzi:
Tel Aviv Univ, Sackler Fac Med, Dept Physiol & Pharmacol, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 rmacol, IL-69978 Tel Aviv, Israel Tel Aviv Univ, Sackler Fac Med, Dept Physiol & Pharmacol, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 rmacol, IL-69978 Tel Aviv, Israel Tel Aviv Univ, Sackler Fac Med, Felstein Med Ctr, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 ed Ctr, IL-69978 Tel Aviv, Israel Tel Aviv Univ, Sackler Fac Med, Geha Psychiat Hosp, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 t Hosp, IL-69978 Tel Aviv, Israel Tel Aviv Univ, Sackler Fac Med, Felsenstein Med Res Ctr, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 es Ctr, IL-69978 Tel Aviv, Israel
Titolo Testata:
EUROPEAN NEUROPSYCHOPHARMACOLOGY
fascicolo: 3, volume: 10, anno: 2000,
pagine: 145 - 150
SICI:
0924-977X(200005)10:3<145:SOSGSI>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
UPTAKE SITES; IMIPRAMINE BINDING; NOREPINEPHRINE UPTAKE; HORMONE-RELEASE; BRAIN-REGIONS; ESTROUS-CYCLE; PROLACTIN; PROGESTERONE; ESTRADIOL; WOMEN;
Keywords:
serotonin transporter; dopamine transporter; estradiol; progesterone; prolactin; testosterone; gonadal hormones;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Rehavi, M Tel Aviv Univ, Sackler Fac Med, Dept Physiol & Pharmacol, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 -69978 Tel Aviv, Israel
Citazione:
M. Rehavi et al., "Suppression of serum gonadal steroids in rats by chronic treatment with dopamine and serotonin reuptake inhibitors", EUR NEUROPS, 10(3), 2000, pp. 145-150

Abstract

The impact of chronic administration (3 weeks) of dopamine and serotonin reuptake inhibitors on serum gonadal steroid hormones and prolactin was studied in intact male and female rats. Both the dopamine and the serotonin reuptake inhibitors lowered serum estradiol and progesterone levels in the female rats. The dopamine transporter blockers suppressed testosterone serum levels in the male rats, whereas serotonin reuptake inhibitors induced only a non-significant reduction (30%) of this hormone. In contrast to the decrease in gonadal steroids, none of the serotonin or the dopamine reuptake blockers altered prolactin serum levels in either the male or female rats. It seems that the effect of these agents on ovarian and testicular hormones isrelated to the impact of the monoamine reuptake inhibitors on the hypothalamic-pituitary-gonadal axis. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:22:26