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Titolo:
Desmosomes and their autoimmune pathologies
Autore:
Cozzani, E; Cacciapuoti, M; Parodi, A; Ghohestani, R; Rebora, A;
Indirizzi:
Univ Genoa, Dermatol Sect, DiSEM, I-16132 Genoa, Italy Univ Genoa Genoa Italy I-16132 ermatol Sect, DiSEM, I-16132 Genoa, Italy Thomas Jefferson Univ, Dept Dermatol & Cutaneous Biol, Philadelphia, PA 19107 USA Thomas Jefferson Univ Philadelphia PA USA 19107 hiladelphia, PA 19107 USA
Titolo Testata:
EUROPEAN JOURNAL OF DERMATOLOGY
fascicolo: 4, volume: 10, anno: 2000,
pagine: 255 - 261
SICI:
1167-1122(200006)10:4<255:DATAP>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
PEMPHIGUS-VULGARIS ANTIGEN; PARANEOPLASTIC PEMPHIGUS; CELL-ADHESION; INTERMEDIATE FILAMENTS; EXTRACELLULAR DOMAIN; HUMAN AUTOANTIBODIES; BLISTER FORMATION; EPITHELIAL-CELLS; TERMINAL DOMAIN; IGA PEMPHIGUS;
Keywords:
autoimmunity; cadherins; cell adhesion; desmosome; epitope spreading; pemphigus;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Cozzani, E Univ Genoa, Dermatol Sect, DiSEM, Vle Benedetto XV 7, I-16132 Genoa, Italy Univ Genoa Vle Benedetto XV 7 Genoa Italy I-16132 Genoa, Italy
Citazione:
E. Cozzani et al., "Desmosomes and their autoimmune pathologies", EUR J DERM, 10(4), 2000, pp. 255-261

Abstract

Desmosomes guarantee the integrity of the epidermis, by functioning both as an adhesive complex and as a cell-surface attachment site for the keratinintermediate filaments of the cytoskeleton. Considerable progress has beenmade in our knowledge of desmosomes and their components. The structure and function of many of the desmosomal molecules have been determined, and a number of the molecular interactions between desmosomal proteins have been elucidated. Desmosomal proteins are major antigens in pemphigus. Each type of pemphigus has its own antigenic targets, but in the last few years it has been shown that certain autoantibody populations are not restricted to just one form of pemphigus. The production of autoantibodies against multipleintracellular and extracellular desmosomal proteins, whose pathogenic roleremains to be elucidated, suggests an overlapping distribution of antibodyspecificities among different forms of pemphigus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 07:35:53