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Titolo:
Antinociceptive, subjective and behavioral effects of smoked marijuana in humans
Autore:
Greenwald, MK; Stitzer, ML;
Indirizzi:
Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Behav Pharmacol Res Unit, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 s Unit, Baltimore, MD 21205 USA
Titolo Testata:
DRUG AND ALCOHOL DEPENDENCE
fascicolo: 3, volume: 59, anno: 2000,
pagine: 261 - 275
SICI:
0376-8716(20000601)59:3<261:ASABEO>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CANNABINOID-INDUCED ANTINOCICEPTION; TAIL-SKIN TEMPERATURE; ANALGESIC PROPERTIES; MEDICAL MARIJUANA; SR 141716A; NALTREXONE; RATS; MICE; DELTA(9)-TETRAHYDROCANNABINOL; DELTA-9-TETRAHYDROCANNABINOL;
Keywords:
marijuana smoking; Delta(9)-tetrahydrocannabinol; antinociception; analgesia; endogenous opioids; naltrexone; subjective effects; performance; heart rate; humans;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Greenwald, MK Wayne State Univ, Sch Med, Dept Psychiat & Behav Neurosci, Res Div Substance Abuse, 2761 E Jefferson Ave, Detroit, MI 48207 USA Wayne State Univ 2761 E Jefferson Ave Detroit MI USA 48207 A
Citazione:
M.K. Greenwald e M.L. Stitzer, "Antinociceptive, subjective and behavioral effects of smoked marijuana in humans", DRUG AL DEP, 59(3), 2000, pp. 261-275

Abstract

The purpose of this study was to determine whether marijuana produced dose-dependent antinociception in humans and, if so, whether endogenous opiatesmodulate this effect. A total of five male regular marijuana users participated in three test sessions during which they smoked cigarettes containing0% (placebo) and 3.55% Delta(9)-tetrahydrocannabinol (Delta(9)-THC) (active). Each of four controlled smoking bouts per session, spaced at 40-min intervals, consisted of nine puffs from active and placebo cigarettes (three cigarettes, three puffs per cigarette, one puff per min). During successive bouts, participants smoked 0, 3. 6 and 9 (0, 3, 9 and 18 cumulative) puffs from active marijuana cigarettes, with the remainder of puffs from placebo cigarettes. Test sessions were identical, except for naltrexone 0, 50 or 200 mg p.o. (randomized, double-blind) administration 1 h before the first smoking bout on the different days. Before smoking, between smoking bouts andpostsmoking, participants completed an assessment battery that included antinociceptive (finger withdrawal from radiant heat stimulation), biological, subjective, observer-rated signs and performance measures. Marijuana produced significant dose-dependent antinociception (increased finger withdrawal latency) and biobehavioral effects. Naltrexone did not significantly influence marijuana dose-effect curves, suggesting no role of endogenous opiates in marijuana-induced antinociception under these conditions. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

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Documento generato il 04/12/20 alle ore 13:14:56