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Titolo:
Effects of nortriptyline and paroxetine on QT variability in patients withpanic disorder
Autore:
Yeragani, VK; Pohl, R; Jampala, VC; Balon, R; Ramesh, C; Srinivasan, K;
Indirizzi:
Wayne State Univ, Sch Med, Dept Psychiat, Detroit, MI USA Wayne State Univ Detroit MI USA Sch Med, Dept Psychiat, Detroit, MI USA Vet Affairs Med Ctr, Dayton, OH USA Vet Affairs Med Ctr Dayton OH USAVet Affairs Med Ctr, Dayton, OH USA Wright State Univ, Sch Med, Dayton, OH USA Wright State Univ Dayton OH USA ight State Univ, Sch Med, Dayton, OH USA St Johns Med Coll Hosp, Bangalore, Karnataka, India St Johns Med Coll Hosp Bangalore Karnataka India alore, Karnataka, India
Titolo Testata:
DEPRESSION AND ANXIETY
fascicolo: 3, volume: 11, anno: 2000,
pagine: 126 - 130
SICI:
1091-4269(2000)11:3<126:EONAPO>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEART-RATE-VARIABILITY; POWER-SPECTRAL-ANALYSIS; SUDDEN CARDIAC DEATH; HOLTER ECG RECORDS; PERIOD VARIABILITY; REPOLARIZATION LABILITY; MYOCARDIAL-INFARCTION; DEPRESSED-PATIENTS; FREQUENCY-DOMAIN; PHOBIC ANXIETY;
Keywords:
QT variability; heart rate variability; panic disorder; autonomic; cardiovascular mortality; sudden cardiac death;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Yeragani, VK Flat 16,KCN Mans,Madhav Nagar, Bangalore 560001, Karnataka, India Flat 16,KCN Mans,Madhav Nagar Bangalore Karnataka India 560001
Citazione:
V.K. Yeragani et al., "Effects of nortriptyline and paroxetine on QT variability in patients withpanic disorder", DEPRESS ANX, 11(3), 2000, pp. 126-130

Abstract

This study investigated bent-to-bent QT variability in patients with panicdisorder before and after treatment with nortriptyline (n = 13) and paroxetine (n = 16), using an automated algorithm to compute QT intervals. An increase in QT variability appears to be associated with symptomatic patients with dilated cardiomyopathy and also with an increased risk for sudden cardiac death. QTvi (QT variability index: a log ratio of QT variance normalized for mean QT over heart rate variability normalized for mean heart rate) was significantly higher in supine posture in patients with panic disorder treated with nortriptyline (P = 0.006) but not paroxetine. Thus paroxetine may be a better drug of choice especially in patients with coexisting cardiac disease. These findings are important especially in view of the recent reports of increased risk for cardiovascular mortality and sudden death in patients with anxiety and depression. QTvi can be a valuable noninvasive measure of temporal repolarization lability, especially to study the side effects of medications which affect cardiac autonomic function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 17:41:33